{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:06:15Z","timestamp":1791324375760,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate FCH\u2010PET\/CT and parathyroid 4D\u2010CT so as to guide surgery in patients with primary hyperparathyroidism (pHPT) and prior neck surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of all patients referred for a FCH\u2010PET\/CT in our institution were systematically reviewed. Only patients with pHPT, a history of neck surgery (for pHPT or another reason) and an indication of reoperation were included. All patients had parathyroid ultrasound (US) and Tc\u201099m\u2010sestaMIBI scintigraphy, and furthermore, some patients had 4D\u2010CT. Gold standard was defined by pathological findings and\/or US\u2010guided fine\u2010needle aspiration with PTH level measurement in the washing liquid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010nine patients were included in this retrospective study. FCH\u2010PET\/CT identified 34 abnormal foci including 19 ectopic localizations. 4D\u2010CT, performed in 20 patients, detected 11 abnormal glands at first reading and 6\u00a0more under FCH\u2010PET\/CT guidance. US and Tc\u201099m\u2010sestaMIBI found concordant foci in 8\/29 patients. Gold standard was obtained for 32 abnormal FCH\u2010PET\/CT foci in 27 patients. On a per\u2010lesion analysis, sensitivity, specificity, positive and negative predictive values were, respectively, 96%, 13%, 77% and 50% for FCH\u2010PET\/CT, 75%, 40%, 80% and 33% for 4D\u2010CT. On a per\u2010patient analysis, sensitivity was 85% for FCH\u2010PET\/CT and 63% for 4D\u2010CT. FCH\u2010PET\/CT results made it possible to successfully remove an abnormal gland in 21 patients, including 12 with a negative or discordant US\/Tc\u201099m\u2010sestaMIBI scintigraphy result, with a global cure rate of 73%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FCH\u2010PET\/CT is a promising tool in the challenging population of reoperative patients with pHPT. Parathyroid 4D\u2010CT appears as a confirmatory imaging modality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-019-04910-6","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T11:57:36Z","timestamp":1547812656000},"page":"1232-1242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["18F\u2010Fluorocholine PET\/CT and Parathyroid 4D Computed Tomography for Primary Hyperparathyroidism: The Challenge of Reoperative Patients"],"prefix":"10.1002","volume":"43","author":[{"given":"Coralie","family":"Amadou","sequence":"first","affiliation":[{"name":"Department of Thyroid and Endocrine Tumours, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Bera","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"},{"name":"Laboratoire d\u2019imagerie biomedicale (LIB), INSERM U1146 Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Ezziane","sequence":"additional","affiliation":[{"name":"Department of Radiology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chami","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019imagerie biomedicale (LIB), INSERM U1146 Sorbonne University Paris France"},{"name":"Department of Radiology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Delbot","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Rouxel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Leban","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine Biochemistry, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Herve","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Menegaux","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, 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