{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:27:05Z","timestamp":1784773625299,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty\u2010one patients were diagnosed with pHPT and PTC concurrently. Pathology results and demographic findings of these patients were compared with 186 patients who underwent thyroidectomy and diagnosed with PTC at the same time interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The co\u2010occurrence of pHPT and PTC was 11.3% (31\/275). The median ages of the pHPT, pHPT\u2009+\u2009PTC, and PTC groups were 55, 57, and 50 years old, respectively (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001). The diameter of tumor was smaller in the pHPT\u2009+\u2009PTC group [median 7\u00a0mm (range 0.5\u201325\u00a0mm) vs. 15\u00a0mm (range 1\u2013100\u00a0mm)], with higher rates of microcarcinomas (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001), than the patients in the PTC group. Examination of tumor morphology showed higher rates of tumor capsule invasion and multicentricity in the pHPT\u2009+\u2009PTC group than those in the isolated PTC group (<jats:italic>p\u2009<\/jats:italic>=\u20090.02, <jats:italic>p\u2009<\/jats:italic>=\u20090.04, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pHPT\u2009+\u2009PTC group had significantly smaller tumor diameter than the PTC group. This result may support the idea that pHPT leads to overdiagnosis of PTC. However, observation of high rates of tumor capsule invasion and multicentricity in the pHPT\u2009+\u2009PTC group may suggest an associative etiology with more aggressive PTC.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-04920-4","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T06:43:12Z","timestamp":1548398592000},"page":"1243-1248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-9784","authenticated-orcid":false,"given":"Kenan","family":"\u00c7etin","sequence":"first","affiliation":[{"name":"Department of General Surgery University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital 34890 Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-303X","authenticated-orcid":false,"given":"Hasan E.","family":"S\u0131kar","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital 34890 Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-755X","authenticated-orcid":false,"given":"\u015eule","family":"Temizkan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Yeditepe University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-8590","authenticated-orcid":false,"given":"Cem B.","family":"Ofluo\u011flu","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital 34890 Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-4617","authenticated-orcid":false,"given":"Ay\u015fenur","family":"\u00d6zderya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-6191","authenticated-orcid":false,"given":"Kadriye","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-7218","authenticated-orcid":false,"given":"Aylin E.","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-0903","authenticated-orcid":false,"given":"Hasan F.","family":"K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital 34890 Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889\u20108529(18)30357\u20108"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60507\u20109"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_6_6_2","unstructured":"NooneAM HowladerN KrapchoMet al (2018)SEER cancer statistics review 1975\u20102015 National Cancer Institute.https:\/\/seer.cancer.gov\/csr\/1975_2015\/ based on November 2017 SEER data submission posted to the SEER web site April 2018. 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Study protocol was approved by Dr. Lutfi Kirdar Kartal Research and Training Hospital in affiliation with University of Medical Sciences\u2019 ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was not obtained from participants due to retrospective design of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}