{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:54:44Z","timestamp":1768002884308,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Young Researcher Fund of Science and Technology Department of Jilin Province","award":["20170520027JH"],"award-info":[{"award-number":["20170520027JH"]}]},{"name":"Norman Bethune Youth Program of Jilin University","award":["2015219"],"award-info":[{"award-number":["2015219"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>One of the presumed advantages of prophylactic central neck dissection (pCND) is offering staging basis for more aggressive radioactive iodine (RAI) therapy, which postulates the necessity of high dose for treatment efficacy. The present study aims to compare the effectiveness between low\u2010dose and high\u2010dose RAI in a select cohort of cN0 papillary thyroid cancer (PTC) patients with pathological N1a (pN1a) disease revealed by pCND in terms of ablation rate and response to therapy. The frequency of short\u2010term adverse effects between the two groups was also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>From January 2014 to April 2016, cN0\u00a0PTC patients with pN1a disease revealed by pCND in our hospital were retrospectively reviewed. Patients with other indications for high\u2010dose RAI, such as the presence of extrathyroidal extension, vascular invasion or suspicions of distant metastasis, were excluded. For the included patients, high dose (3700\u00a0MBq) was administered between January 2014 and August 2015 and low dose (1110\u00a0MBq) between August 2015 and April 2016. Ablation assessment was performed 6\u00a0months after RAI therapy. Response evaluation after RAI therapy was performed after 46.3 \u00b1 9.5\u00a0months for high\u2010dose group and 29.1 \u00b1 2.6\u00a0months for low\u2010dose group. All patients were also evaluated for short\u2010term adverse effects 24 and 72 hours after RAI administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 84 patients were enrolled. Among them, 42 were in the high\u2010dose group and the other 42\u00a0in the low\u2010dose group. There was no significant difference in ablation rate (P = 0.7707) and response to RAI therapy (P = 0.6454) between the two groups. Twenty\u2010four hours after RAI administration, neck pain and swelling (33.3% VS. 11.9%; P = 0.0372) and gastrointestinal discomfort (45.2% vs. 21.4%; P = 0.0373) were significantly more frequent in the high\u2010dose group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose RAI therapy, with higher frequency of short\u2010term adverse effects, appears to be not superior to low\u2010dose RAI therapy for cN0\u00a0PTC patients with pN1a disease revealed by pCND to achieve better response to therapy. Further randomized studies with larger series of patients and longer follow\u2010up duration, especially with the low\u2010dose group, are needed to validate our results.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-04924-0","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T18:16:03Z","timestamp":1548440163000},"page":"1256-1263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010Dose RAI Therapy Justified by Pathological N1a Disease Revealed by Prophylactic Central Neck Dissection for cN0\u00a0Papillary Thyroid Cancer Patients: Is it Superior to Low\u2010Dose RAI Therapy?"],"prefix":"10.1002","volume":"43","author":[{"given":"Lan","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine China\u2010Japan Union Hospital of Jilin University No. 126, Xiantai Street Changchun Jilin Province 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