{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:18:45Z","timestamp":1786979925525,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Butterfly Thyroid Cancer Trust","award":["0317"],"award-info":[{"award-number":["0317"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2019,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The inability to identify the pathological gland at surgery results in failure to cure hyperparathyroidism in 2\u20135%. The poorly understood characteristic of parathyroid tissue to manifest autofluorescence (AF) under near\u2010infrared (NIR) light has been promoted as an intraoperative adjunct in parathyroid surgery. This study sought to explore potential clinical correlates for AF and assess the clinical utility of AF in parathyroid surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients undergoing parathyroid surgery for primary and renal disease were included. NIR imaging was used intraoperatively and the degree of AF of parathyroid glands graded by the operating surgeon. Variables assessed for correlation with AF were: pre\u2010operative serum calcium and PTH, SestaMIBI positivity, gland weight and histological composition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety\u2010six patients underwent parathyroidectomy over an 8\u2010month period: 49 bilateral explorations, 41 unilateral and 6 focussed lateral approaches: 284 potentially \u2018visualisable\u2019 glands in total. Two hundred and fifty\u2010seven glands (90.5%) were visualised with NIR. Correlation was found between the degree of fluorescence and pre\u2010operative serum calcium and PTH, but not between gland weight and SestaMIBI positivity. In those with renal hyperparathyroidism, a predominance of oxyphil cells correlated with increased AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autofluorescence intensity correlates with serum calcium, PTH and gland composition. Further refinements would be required for this information to be of value in a clinical setting. Improvements allowing NIR to visualise the additional 9.5% of parathyroids and overcome the variation in signal intensity due to depth of access are required for the routine adoption of this technology. At present, its routine use in a clinical setting cannot be justified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-019-04929-9","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T19:13:10Z","timestamp":1549653190000},"page":"1532-1537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Autofluorescence in Parathyroidectomy: Signal Intensity Correlates with Serum Calcium and Parathyroid Hormone but Routine Clinical Use is Not Justified"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0079-1194","authenticated-orcid":false,"given":"Aimee","family":"DiMarco","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Hammersmith Hospital Du Cane Road W12 0HS London UK"},{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Chotalia","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Hammersmith Hospital Du Cane Road W12 0HS London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Bloxham","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Hammersmith Hospital Du Cane Road W12 0HS London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Hammersmith Hospital Du Cane Road W12 0HS London UK"},{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Tolley","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Hammersmith Hospital Du Cane Road W12 0HS London UK"},{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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