{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:05:22Z","timestamp":1777331122628,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Margarete und Walter Lichtenstein Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Incisional hernia, a serious complication after laparotomy, is associated with high morbidity and costs. This trial examines the value of prophylactic intraperitoneal onlay mesh to reduce the risk of incisional hernia after a median follow\u2010up time of 5.3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a parallel group, open\u2010label, single center, randomized controlled trial (NCT01003067). After midline incision, the participants were either allocated to abdominal wall closure according to Everett with a PDS\u2010loop running suture reinforced by an intraperitoneal composite mesh strip (Group <jats:italic>A<\/jats:italic>) or the same procedure without the additional mesh strip (Group <jats:italic>B<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 276 patients were randomized (Group <jats:italic>A<\/jats:italic>\u2009=\u2009131; Group <jats:italic>B<\/jats:italic>\u2009=\u2009136). Follow\u2010up data after a median of 5.3 years after surgery were available from 183 patients (Group <jats:italic>A<\/jats:italic>\u2009=\u200995; Group <jats:italic>B<\/jats:italic>\u2009=\u200988). Incisional hernia was diagnosed in 25\/95 (26%) patients in Group <jats:italic>A<\/jats:italic> and in 46\/88 (52%) patients in Group <jats:italic>B<\/jats:italic> (risk ratio 0.52; 95% CI 0.36\u20130.77; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Eighteen patients with asymptomatic incisional hernia went for watchful waiting instead of hernia repair and remained free of symptoms after of a median follow\u2010up of 5.1 years. Between the second\u2010 and fifth\u2010year follow\u2010up period, no complication associated with the mesh could be detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of a composite mesh in intraperitoneal onlay position significantly reduces the risk of incisional hernia during a 5\u2010year follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p>Ref. NCT01003067 (clinicaltrials.gov).<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-04964-6","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T12:52:53Z","timestamp":1551444773000},"page":"1669-1675","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prophylactic Intraperitoneal Onlay Mesh Following Midline Laparotomy\u2014Long\u2010Term Results of a Randomized Controlled Trial"],"prefix":"10.1002","volume":"43","author":[{"given":"Philippe M.","family":"Glauser","sequence":"first","affiliation":[{"name":"Department of Surgery Hospital of Baselland University of Basel Liestal Switzerland"},{"name":"Department of General Surgery University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Brosi","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital of Baselland University of Basel 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March 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2019","order":2,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":3,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original version of the article, Philippe M. Glauser\u2019s, Philippe Brosi\u2019s, Benjamin Speich\u2019s, Samuel A. K\u00e4ser\u2019s, Andres Heigl\u2019s, and Christoph A. Maurer\u2019s first and last names were interchanged. The names are correct as reflected here. The original article has been corrected.","order":4,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Philippe M. Glauser, MD, Philippe Brosi, MD, Benjamin Speich, PhD, Samuel A. K\u00e4ser A., MD, Andres Heigl, MD, Robert Rosenberg, MD, and Christoph A. Maurer, MD have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}