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Non\u2010surgical minimally invasive modalities, including radiofrequency ablation (RFA), have been widely used with good results. The factors related to the efficacy of RFA are still debated. This study was to evaluate the safety, efficacy and related factors of RFA in the treatment of benign thyroid nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single\u2010center study was conducted on 251 benign thyroid nodules in 184 patients treated with RFA. The procedure was performed under ultrasound (US) guidance using the trans\u2010isthmic approach and the moving\u2010shot technique. Clinical and US examinations were performed at 1, 3, 6, 12\u00a0months, and then at 6\u00a0month intervals. Study outcomes were volume reduction ratio (VRR) and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 153 women and 31\u00a0men included in the study. The mean age was 43.9 years. The median initial largest diameter and volume of nodules were 30\u00a0mm and 6.18\u00a0ml. The median length of follow\u2010up was 12\u00a0months. Two minor complications were found. The mean VRR was 66.8; 74.3; and 81% after 3, 6, and 12\u00a0months, respectively. Initial solidity was a factor related to the efficacy: cystic nodules had higher VRR compared to solid ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RFA is safe, effective and can be used as a routine treatment for benign thyroid nodules. More prospective multicenter studies with long\u2010term follow\u2010up are required to improve the safety and efficacy of RFA.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05044-5","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:02:26Z","timestamp":1559667746000},"page":"2447-2453","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Radiofrequency Ablation for Benign Thyroid Nodules: 1\u2010Year Follow\u2010Up in 184\u00a0Patients"],"prefix":"10.1002","volume":"43","author":[{"given":"Nguyen Lam","family":"Vuong","sequence":"first","affiliation":[{"name":"Department of Medical Statistics and Informatics, Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"},{"name":"Thoracic and Vascular Department University Medical Center at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Quang","family":"Dinh","sequence":"additional","affiliation":[{"name":"Thoracic and Vascular Department University Medical Center at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Tat","family":"Bang","sequence":"additional","affiliation":[{"name":"Thoracic and Vascular Department University Medical Center at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-2439","authenticated-orcid":false,"given":"Tran Thi Mai","family":"Thuy","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Hoang","family":"Bac","sequence":"additional","affiliation":[{"name":"University Medical Center at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thanh","family":"Vy","sequence":"additional","affiliation":[{"name":"Thoracic and Vascular Department University Medical Center at Ho Chi Minh City Ho Chi Minh City Vietnam"},{"name":"Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346587"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp031436"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010008\u20109484\u20101"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010008\u20109479\u2010y"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.4.632"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","unstructured":"Bandeira\u2010EchtlerE BergerhoffK RichterBet al. 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