{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:58:57Z","timestamp":1783097937365,"version":"3.54.6"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of parathyroidectomy (PTx) timing on serum calcium (Ca) levels and renal functions in renal transplant recipients with severe hyperparathyroidism (HPT) remains unclear. We retrospectively aimed to investigate and compare the clinical data of patients who underwent pre\u2010 and post\u2010transplant PTx and elucidated the impact of PTx timing on serum Ca levels and renal graft outcomes after renal transplantation (RTx).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During January 2000\u2013December 2016, 53 and 55 patients underwent post\u2010transplant PTx (Post\u2010RTx group) and pretransplant PTx (Pre\u2010RTx group), respectively. The serum Ca levels and estimated glomerular filtration rate (eGFR) were assessed in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the follow\u2010up, the serum Ca levels were significantly higher and the incidence of hypocalcemia was significantly lower in the Pre\u2010RTx group than in the Post\u2010RTx group [9.5 vs. 8.9\u00a0mg\/dL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; 14.5% vs. 34.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.024]. The decrease in the eGFR 12\u201336\u00a0months after RTx was more significant in the Post\u2010RTx group than in the Pre\u2010RTx group (\u221213.8% vs. \u22120.9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). A logistic regression involving age, sex, dialysis period, and serum parathormone level revealed that post\u2010transplant PTx is an independent risk factor for persistent hypocalcemia at the end of the follow\u2010up (<jats:italic>P<\/jats:italic>\u2009=\u20090.034) and for a &gt;20% decrease in the eGFR 12\u201336\u00a0months after RTx (<jats:italic>P<\/jats:italic>\u2009=\u20090.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In renal transplant candidates with severe HPT, pretransplant PTx should be considered to prevent persistent hypocalcemia and deterioration of the renal graft function.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05124-6","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T16:03:30Z","timestamp":1565366610000},"page":"498-507","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of Pre\u2010 and Post\u2010transplant Parathyroidectomy in Renal Transplant Recipients and the Impact of Parathyroidectomy Timing on Calcium Metabolism and Renal Allograft Function: A Retrospective Single\u2010Center Analysis"],"prefix":"10.1002","volume":"44","author":[{"given":"Manabu","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Hiramitsu","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Ichimori","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Narumi","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Watarai","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Nagoya Daini Red Cross Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya 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August 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Institutional Review Board of Nagoya Daini Red Cross Hospital and was conducted according to the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human rights"}},{"value":"Informed consent was obtained from all individual participants included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}