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We analyzed the National Cancer Database (NCDB) to assess current trends in disease incidence, patient demographics, cancer treatment, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The NCDB was queried to identify patients diagnosed with pleural mesothelioma from 2004 through 2014. Clinical and pathologic characteristics, treatments, and survival were analyzed. Risk factors for death were identified by multivariable Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20,988 patients with pleural mesothelioma were reported to the NCDB. The number of cases per year increased from 1783 to 1961, accounting for roughly 0.3% of all reported cancers each year. The proportion of elderly patients increased from 75 to 80%, but distribution by sex remained constant (20% female). The proportion of patients undergoing treatment increased from 34 to 54%. One\u2010year survival increased from 37 to 47% and 3\u2010year survival from 9 to 15% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Factors associated with improved survival included younger age, female sex, epithelioid histology, treatment in an academic center, health insurance, higher income, and multimodality therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The annual incidence of mesothelioma has not declined this century and remains stable. Reporting of histologic and clinical staging has improved. National trends suggest that survival is slowly increasing despite an aging cohort. Multimodal therapy and treatment at academic centers are modifiable risk factors associated with improved survival.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05132-6","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T17:02:43Z","timestamp":1566234163000},"page":"3239-3247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Largely Unchanged Annual Incidence and Overall Survival of Pleural Mesothelioma in the USA"],"prefix":"10.1002","volume":"43","author":[{"given":"Hari B.","family":"Keshava","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz Umair","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Bribriesco","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudish C.","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Center, Heart and Vascular Institute Cleveland Clinic 9500 Euclid Avenue \/ Mail Stop J4\u20101 44195 Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196503182721104"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03060270028006"},{"key":"e_1_2_8_4_1","first-page":"260","article-title":"Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province","volume":"17","author":"Wagner JC","year":"1960","journal-title":"Br J Ind Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11151"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2004.04.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201010\u20100190"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971215)80:12<2296::AID-CNCR11>3.0.CO;2-P"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010009\u20100771\u20103"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10125"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.10.054"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.12.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_8_14_1","unstructured":"National cancer database\u2014PUF data dictionary items.https:\/\/ncdbpuf.facs.org\/node\/259. 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