{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:50:31Z","timestamp":1789426231363,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["BIRD172205"],"award-info":[{"award-number":["BIRD172205"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["BIRD172205"],"award-info":[{"award-number":["BIRD172205"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hyperparathyroidism\u2010jaw tumor syndrome (HPT\u2010JT) is a rare disease caused by\n                      <jats:italic>CDC73<\/jats:italic>\n                      germline mutations, with familial primary hyperparathyroidism (pHPT), ossifying jaw tumors, genito\u2010urinary neoplasms. The present study was aimed at determining the long\u2010term postoperative outcome of parathyroidectomy in HPT\u2010JT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of a single\u2010center series of 20 patients from five unrelated HPT\u2010JT families undergoing parathyroid surgery was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pathology confirmed a single\u2010gland involvement in 95% of cases at onset. Parathyroid carcinoma occurred in three patients undergoing en\u2010bloc parathyroidectomy and thyroid lobectomy: parathyroid benign lesions in 17 patients undergoing subtotal parathyroidectomy for evident multiglandular involvement (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) or selective parathyroidectomy for single\u2010gland involvement (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916), during bilateral (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913) or targeted unilateral neck exploration (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097). At a median overall follow\u2010up of 16 years (range 2.5\u201342), patients with parathyroid carcinoma had a persistent\/recurrent disease in 66.6%; patients with benign lesions had recurrent pHPT in 23.5% after a prolonged disease\u2010free period; recurrent benign pHPT occurred slightly more often in cases of discordant preoperative localization (60% vs 9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>pHPT in HPT\u2010JT is generally characterized by a benign and single\u2010gland involvement, with a relatively increased risk of malignancy (15%). Parathyroid carcinoma needs extensive surgery because of high risk of permanent\/recurrent disease (66.6%). In benign involvement, targeted unilateral exploration with selective parathyroidectomy may be effective in cases of concordant single\u2010gland localization at preoperative localization imaging techniques. Bilateral neck exploration with subtotal parathyroidectomy might be preferred in cases of negative or discordant preoperative localization, because of the increased risk of multiglandular involvement and long\u2010term recurrences (23.5%).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-019-05156-y","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T15:03:22Z","timestamp":1567782202000},"page":"508-516","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Long\u2010Term Outcomes of Parathyroidectomy in Hyperparathyroidism\u2010Jaw Tumor Syndrome: Analysis of Five Families with\n                    <i>CDC73<\/i>\n                    Mutations"],"prefix":"10.1002","volume":"44","author":[{"given":"Maurizio","family":"Iacobone","sequence":"first","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology University of Padua Via Giustiniani 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Camozzi","sequence":"additional","affiliation":[{"name":"Endocrinogy Unit, Department of Medicine University of Padua Via Giustiniani 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Mian","sequence":"additional","affiliation":[{"name":"Endocrinogy Unit, Department of Medicine University of Padua Via Giustiniani 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmaria","family":"Pennelli","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Medicine University of Padua Via Giustiniani 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Pagetta","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology University of Padua Via Giustiniani 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Casal Ide","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology University of Padua Via Giustiniani 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Masi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Padua Via Gabelli 63 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Zovato","sequence":"additional","affiliation":[{"name":"Familial Tumor Unit Veneto Institute of Oncology, (IOV)\u2010IRCCS Via Gattamelata, 64 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Torresan","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology 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