{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:52:12Z","timestamp":1761897132088},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been reported that both fibrinogen and the neutrophil\u2013lymphocyte ratio (NLR) are related to the degree of malignancy in various types of cancer. This study compared the combined index of fibrinogen and NLR (F\u2010NLR) with NLR alone for predicting the prognosis of patients with resectable gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data on 666 patients with resectable gastric cancer. Patients were divided into three F\u2010NLR score groups based on the following criteria: score 2, both hyperfibrinogenemia (\u2265350\u00a0mg\/dl) and high NLR (\u22652.5); score 1, either hyperfibrinogenemia or high NLR; and score 0, neither abnormality. The association between prognosis and NLR alone or F\u2010NLR was evaluated using the Kaplan\u2013Meier method and Cox multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high\u2010NLR group had significantly worse overall survival (OS) than the low\u2010NLR group (hazard ratio 1.62; 95% confidence interval [CI] 1.07\u20132.45; log\u2010rank <jats:italic>P<\/jats:italic>\u2009=\u20090.022), but there was no significant difference between the high\u2010 and low\u2010NLR groups after adjusting for the fibrinogen level. F\u2010NLR groups showed significantly different OS (log\u2010rank <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and recurrence\u2010free survival (log\u2010rank <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The 5\u2010year OS rate for the groups with F\u2010NLR scores of 2, 1, and 0 was 72.6%, 81.4%, and 90.4%, respectively. A Cox multivariate analysis of OS revealed that a high F\u2010NLR score (1 or 2) was an independent prognostic factor (<jats:italic>P<\/jats:italic>\u2009=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>F\u2010NLR was an independent prognostic factor in patients with gastric cancer and a more useful prognostic indicator than NLR alone.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05193-7","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T22:51:30Z","timestamp":1569538290000},"page":"207-212","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic Value of the Combined Index of Plasma Fibrinogen and the Neutrophil\u2013Lymphocyte Ratio in Gastric Cancer"],"prefix":"10.1002","volume":"44","author":[{"given":"Masaaki","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Osaka University Graduate School of Medicine 2\u20102\u2010E2, Yamadaoka 565\u20100871 Suita Osaka Japan"},{"name":"Department of Surgery JCHO Hoshigaoka Medical Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinori","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Osaka University Graduate School of Medicine 2\u20102\u2010E2, Yamadaoka 565\u20100871 Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Osaka University Graduate School of Medicine 2\u20102\u2010E2, Yamadaoka 565\u20100871 Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Osaka University Graduate School of Medicine 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