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The majority of deaths and disability occur in low\u2010 and middle\u2010income countries including Ghana. This 3\u2010year retrospective review aimed to define, for the first time, the characteristics and outcomes of neonatal surgical conditions in northern Ghana.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted to include all admissions to the Tamale Teaching Hospital (TTH) neonatal intensive care unit (NICU) with surgical conditions between January 2014 and January 2017. Data were collected on demographics, diagnosis and outcomes. Descriptive analysis was performed on all data, and logistic regression was used to predict determinants of neonatal mortality. <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05 was deemed significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and forty\u2010seven neonates were included. Two hundred and sixty\u2010one (75.2%) were aged 7\u00a0days or less at presentation, with males (<jats:italic>n\u2009<\/jats:italic>=\u2009177, 52%) slightly higher than females (<jats:italic>n\u2009<\/jats:italic>=\u2009165, 48%). The majority were delivered by spontaneous vaginal delivery (<jats:italic>n\u2009<\/jats:italic>=\u2009247, 88%); 191 (58%) were born in hospital. Congenital anomalies accounted for 302 (87%) of the neonatal surgical cases and 45 (96%) deaths. The most common anomalies were omphalocele (<jats:italic>n\u2009<\/jats:italic>=\u200948, 13.8%), imperforate anus (<jats:italic>n\u2009<\/jats:italic>=\u200934, 9.8%), intestinal obstruction (<jats:italic>n\u2009<\/jats:italic>=\u200929, 8.4%), spina bifida (<jats:italic>n\u2009<\/jats:italic>=\u200926, 7.5%) and hydrocephalus (<jats:italic>n\u2009<\/jats:italic>=\u200919, 5.5%). The overall mortality rate was 13.5%. Two\u2010thirds of the deaths (<jats:italic>n\u2009<\/jats:italic>=\u200930) from congenital anomalies were conditions involving the digestive system with gastroschisis having the highest mortality of 88%. Omphalocele (<jats:italic>n\u2009<\/jats:italic>=\u200911, 23.4%), gastroschisis (<jats:italic>n\u2009<\/jats:italic>=\u20097, 14.9%) and imperforate anus (<jats:italic>n\u2009<\/jats:italic>=\u20096, 12.8%) contributed to the most deaths. On multivariate analysis, low birthweight was significantly associated with mortality (OR 3.59, CI 1.4\u20139.5, <jats:italic>p\u2009<\/jats:italic>=\u20090.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Congenital anomalies are a major global health problem associated with high neonatal mortality in Ghana. The highest burden in terms of both caseload and mortality is attributed to congenital anomalies involving the digestive system, which should be targeted to improve outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05210-9","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T18:09:40Z","timestamp":1570126180000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Burden of Neonatal Surgical Conditions in Northern Ghana"],"prefix":"10.1002","volume":"44","author":[{"given":"Alhassan","family":"Abdul\u2010Mumin","sequence":"first","affiliation":[{"name":"School of Medicine and Health Sciences University for Development Studies Tamale Ghana"},{"name":"Tamale Teaching Hospital Salaga Road Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theophilus T. 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