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Previously, we reported that preoperative alkaline phosphatase is a major factor predicting prolonged hospital stay. Nonetheless, some patients with low alkaline phosphatase levels presented with hungry bone syndrome, suggesting that additional factors may play a role.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From September 2010 to December 2017, consecutive dialysis patients who underwent parathyroidectomy for secondary hyperparathyroidism were analyzed. Length of hospital stay was used as a surrogate marker for postoperative bone hunger.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 260 patients were included in the study. The median postoperative hospital stay was 3\u00a0days, and 69 (27%) patients had a stay longer than 3\u00a0days. Multivariate logistic regression analysis revealed that alkaline phosphatase (odds ratio [OR]\u2009=\u20091.005), osteocalcin (OR\u2009=\u20091.001), and subtotal parathyroidectomy (OR\u2009=\u20090.061) were associated with prolonged hospital stay. Multivariate linear regression analysis indicated that age (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212\u20090.170), alkaline phosphatase (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.430), and osteocalcin (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.166) were correlated with the length of stay. After surgery, the median osteocalcin level increased from 264 to 478\u00a0ng\/mL (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alkaline phosphatase is the main predictor of hungry bone syndrome after parathyroidectomy, and preoperative osteocalcin is an additional independent predictor. Patients with a high osteocalcin level may prone to have a higher demand for calcium supplementation.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05251-0","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T20:04:37Z","timestamp":1572293077000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Osteocalcin is an Independent Predictor for Hungry Bone Syndrome After Parathyroidectomy"],"prefix":"10.1002","volume":"44","author":[{"given":"Wen\u2010Ching","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay Medical College 92, Section\u00a02, Chung\u2010Shan North Road 10449 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay 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Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Ping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay Medical College 92, Section\u00a02, Chung\u2010Shan North Road 10449 Taipei Taiwan"},{"name":"Department of Pharmacology School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205624"},{"key":"e_1_2_8_3_1","first-page":"CD006254","article-title":"Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients","volume":"12","author":"Ballinger AE","year":"2014","journal-title":"Cochrane Database Syst 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