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The aim of this study was to investigate the difference in long\u2010term HR\u2010QoL in patients undergoing total gastrectomy versus Ivor Lewis esophagectomy in a tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a follow\u2010up of &gt;1 year after a total gastrectomy or an Ivor Lewis esophagectomy for GEJ\/cardia carcinoma completed the EORTC QLQ\u2010C30 and EORTC QLQ\u2010OG25 questionnaires. \u2018Problems with eating,\u2019 \u2018reflux,\u2019 and \u2018nausea and vomiting\u2019 were the primary HR\u2010QoL endpoints. The secondary endpoints were the remaining HR\u2010QoL domains, postoperative complications and pathology results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients after gastrectomy and 71 after esophagectomy were included. Mean age was 63 years. Median follow\u2010up was 2 years (range 12\u201384\u00a0months). Patients after gastrectomy reported less \u2018choking when swallowing\u2019 and \u2018coughing\u2019 (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212\u20095.952, 95% CI \u2212\u20099.437 to \u2212\u20092.466; <jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212\u200913.084, 95% CI \u2212\u200918.525 to \u2212\u20097.643). More lymph nodes were resected in esophagectomy group (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). No difference was found in number of positive lymph nodes, R0 resection or postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After a follow\u2010up of &gt;1 year \u2018choking when swallowing\u2019 and \u2018coughing\u2019 were less common after a total gastrectomy. No differences were found in postoperative complications or radicality of surgery. Based on this study, no general preference can be given to either of the procedures for GEJ cancer. These results support shared decision making when a choice between the two treatment options is possible.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05281-8","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T18:02:18Z","timestamp":1573840938000},"page":"838-848","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010Term Quality of Life After Total Gastrectomy Versus Ivor Lewis Esophagectomy"],"prefix":"10.1002","volume":"44","author":[{"given":"E.","family":"Jezerskyte","sequence":"first","affiliation":[{"name":"Department of Surgery Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam Meibergdreef 9 Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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Jezerskyte, L.M. Saadeh, E.R.C. Hagens, M.A.G. Sprangers, L. Noteboom, PhD, W.J. Eshuis and S.S. Gisbertz have no conflicts of interest to declare. M.I. van Berge Henegouwen has a consultant role with Mylan, Johnson and Johnson and Medtronic. Research funding from Olympus and Stryker. H.W.M. van Laarhoven has a consultant or advisory role with BMS, Lilly, MSD, Nordic Pharma, Servier and has research funding from Bayer, BMS, Celgene, Janssen, Lilly, Nordic Pharma, Philips, Roche, Servier.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}