{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:00:23Z","timestamp":1784894423591,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether chronic lymphocytic thyroiditis (CLT) influences the risk of development and the progression of papillary thyroid cancer (PTC) remains uncertain. We investigated the effects of CLT on the clinicopathologic features and prognosis of PTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two thousand nine hundred twenty\u2010eight consecutive patients with PTC treated between 2009 and 2017 were divided into two groups: one with chronic lymphocytic thyroiditis and one without; 1174 (40%) of the patients had coincident CLT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In univariate analysis, CLT correlated positively with small tumor size, frequent extrathyroidal extension, multifocal diseases, and p53 but negatively with central lymph node (LN) metastasis and BRAF mutation. In multivariate analysis, CLT was associated with extrathyroidal extension and multifocal disease; however, it was not a prognostic factor for recurrence even though it was associated with two aggressive factors. Compared with patients with PTC alone, there were more retrieved central LNs in the PTC\u2009+\u2009CLT group, and these patients also underwent more invasive diagnostic tests such as fine needle aspiration cytology and frozen biopsy of LN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CLT patients with PTC had better behavior features and prognoses than did those with PTC alone despite frequent multifocality and extrathyroidal extension. However, precaution may be necessary to avoid performing invasive diagnostic procedures for lateral LN metastasis and to manage the patients appropriately.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-05337-9","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T20:02:36Z","timestamp":1578513756000},"page":"1506-1513","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Association Between Chronic Lymphocytic Thyroiditis and the Progress of Papillary Thyroid Cancer"],"prefix":"10.1002","volume":"44","author":[{"given":"Inhwa","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Ajou University Medical Center 164, World cup\u2010ro, Yeongtong\u2010gu Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeung Kyoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Ajou University Medical Center 164, World cup\u2010ro, Yeongtong\u2010gu Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euy Young","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Surgery Ajou University Medical Center 164, World cup\u2010ro, Yeongtong\u2010gu Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Ajou University Medical Center 164, World cup\u2010ro, Yeongtong\u2010gu Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022\u2010007\u20100002\u2010z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320954"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.09.020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021194"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20102978"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01940"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2002.098"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20106413\u20104\u201010"},{"key":"e_1_2_7_11_1","first-page":"23","article-title":"Evaluation of chemiluminescence immunoassays for detecting thyroglobulin (Tg) and thyroid peroxidase (TPO) autoantibodies using the IMMULITE 2000 system","volume":"46","author":"Bohuslavizki KH","year":"2000","journal-title":"Clin Lab"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009\u20109120(03)00114\u20100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.07.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18620"},{"key":"e_1_2_7_15_1","volume-title":"TNM classification of malignant tumours","author":"Brierley JD","year":"2017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17\u20100191"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201056\u20102\u2010251"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.008474"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.1995.tb01894.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u2010117892"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.034"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.32.12.2145"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486367"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002674"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010011\u20101732\u20106"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2014.04.006"},{"key":"e_1_2_7_27_1","first-page":"1","article-title":"The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer?","volume":"33","author":"Del Rio P","year":"2008","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_7_28_1","first-page":"932","article-title":"Risk factors for central lymph node metastasis of patients with papillary thyroid microcarcinoma: a meta\u2010analysis","volume":"7","author":"Liu Z","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103835(97)00398\u20104"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.09.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.960"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0373"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201005\u20101729"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0144"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2009.03699.x"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-019-05337-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-019-05337-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-019-05337-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-019-05337-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T04:20:35Z","timestamp":1703391635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-019-05337-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1007\/s00268-019-05337-9"],"URL":"https:\/\/doi.org\/10.1007\/s00268-019-05337-9","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]},"assertion":[{"value":"8 January 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This work was supported by the new faculty research fund of Ajou University School of Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was not obtained because of the retrospective chart review study design and use of only deidentified clinicopathological information. The study protocol was approved by the Institutional Review Board of Ajou Medical Centre (AJIRB-MED-MDB-19-090).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}