{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:50:39Z","timestamp":1790740239376,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intra\u2010abdominal candidiasis (IAC) is the predominant type of invasive candidiasis with high mortality in surgical intensive care patients. The purpose of this study was to investigate the impact of appropriate source control and antifungal therapy on the outcomes of critically ill surgical patients with IAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective single\u2010center cohort study. Adult surgical patients who were admitted to the intensive care unit and diagnosed with IAC from January 1, 2003, to December 31, 2016, were enrolled. The patients\u2019 data including risk factors of IAC, infection\u2010related information, antifungal treatment and 30\u2010day outcomes were collected. The primary endpoint was 30\u2010day mortality. A COX proportional hazards model was used to analyze the association between appropriate treatment and 30\u2010day survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 82 patients were included in the analysis. Of these, 45 (54.9%) were complicated with septic shock at IAC diagnosis. Types of IAC included peritonitis (61.0%), intra\u2010abdominal abscesses (23.2%) and biliary tract infections (15.9%). Of the included patients, 53 (64.6%) received appropriate source control and 44 (53.7%) appropriate antifungal therapy. Compared with patients with neither of these treatments, appropriate source control (HR 0.08, 95% CI 0.02\u20130.30;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), appropriate antifungal therapy (HR 0.14, 95% CI 0.04\u20130.55;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005), and a combination of these treatments (HR 0.02, 95% CI 0.00\u20130.08;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) were associated with reduced risk of death within 30\u00a0days after IAC diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For critically ill surgical patients with IAC, both appropriate source control and appropriate antifungal therapy were associated with reduced risk of 30\u2010day mortality, and the protective effects of the two appropriate treatments were additive.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-020-05380-x","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T20:17:38Z","timestamp":1579637858000},"page":"1459-1469","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Appropriate Source Control and Antifungal Therapy are Associated with Improved Survival in Critically Ill Surgical Patients with Intra\u2010abdominal Candidiasis"],"prefix":"10.1002","volume":"44","author":[{"given":"Ting","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Peking University First Hospital No.8 Xishiku Street 100034 Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Peking University First Hospital No.8 Xishiku Street 100034 Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Li","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai\u2010Nan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-1836","authenticated-orcid":false,"given":"Dong\u2010Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Peking University First Hospital No.8 Xishiku Street 100034 Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010015\u20101458\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819efac0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010009\u20108249\u20106"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000201889.39443.D2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.12.1341"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010015\u20103866\u20102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000433309.21148.f7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010015\u20103894\u2010y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010013\u20103134\u20102"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis305"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3640\u20103645.2005"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr511"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.512300"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153247"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010016\u20102775\u20109"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.17.11528-2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010013\u20103109\u20103"},{"key":"e_1_2_11_19_1","unstructured":"National Committee for Clinical Laboratory Standards (NCCLS)(1997)Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard\u2010second edition. 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