{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T14:33:30Z","timestamp":1748010810392},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The outcomes of liver resection (LR) with a narrow margin in patients with transplantable hepatocellular carcinoma (HCC) have not been studied. The aim was to assess whether narrow margin following up\u2010front LR impacts the incidence, timing, pattern, and transplantability of tumor recurrence in patients with initially transplantable HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All initially transplantable HCC patients undergoing hepatectomy with either narrow (&lt;10\u00a0mm) or wide (\u226510\u00a0mm) margins from 2007 to 2016 at four Western university centers were compared in terms of recurrence, transplantability of recurrence, recurrence\u2010free survival (RFS), and intention\u2010to\u2010treat overall survival (ITT\u2010OS). Independent predictors of non\u2010transplantability of recurrence were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 187 patients (narrow group, <jats:italic>n<\/jats:italic>\u2009=\u2009107 vs. wide group, <jats:italic>n<\/jats:italic>\u2009=\u200980). Recurrence was significantly more frequent in the narrow margin group (44% vs. 26%; <jats:italic>p<\/jats:italic>\u2009=\u20090.01) with a shorter RFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). The transplantability of recurrence and ITT\u2010OS were, however, not different between the two groups. The presence of satellite nodules on the resected specimens emerged as the sole independent predictor of non\u2010transplantability of tumor recurrence. The stratification of the analysis according to the presence of cirrhosis achieved essentially the same results as in the whole study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Narrow margin was associated with a higher tumor recurrence rate and a shorter RFS for patients with initially transplantable HCC. However, transplantability of recurrence and long\u2010term ITT\u2010OS were not impaired.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05424-2","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T20:09:33Z","timestamp":1582574973000},"page":"1966-1974","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact on Oncological Outcomes and Intent\u2010to\u2010Treat Survival of Resection Margin for Transplantable Hepatocellular Carcinoma in All\u2010Comers and in Patients with Cirrhosis: A Multicenter Study"],"prefix":"10.1002","volume":"44","author":[{"given":"Chetana","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Goumard","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Casellas\u2010Robert","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery Hospital Universitari Dr. Josep Trueta Girona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Lopez\u2010Ben","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery Hospital Universitari Dr. Josep Trueta Girona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Llad\u00f3","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation Hospital Universitari de Bellvitge, CIBERehd. Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli","family":"Busquets","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation Hospital Universitari de Bellvitge, CIBERehd. Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chady","family":"Salloum","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP Paul Brousse Hospital Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Albiol\u2010Quer","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery Hospital Universitari Dr. Josep Trueta Girona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Castro\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery Hospital Universitari Dr. Josep Trueta Girona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Rosmorduc","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille","family":"Feray","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP Paul Brousse Hospital Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation Hospital Universitari de Bellvitge, CIBERehd. 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