{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:56:25Z","timestamp":1775609785512,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parathyroidectomy is the treatment of choice in primary hyperparathyroidism (PHPT). Following surgery, significant changes in bone and mineral metabolism may follow, but routine magnesium monitoring is not standard practice. The occurrence of significant clinical events linked to hypomagnesaemia in 3 patients after parathyroidectomy led to our evaluation of magnesium levels after surgery for PHPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum magnesium levels before and after parathyroidectomy for PHPT were prospectively evaluated in a single centre over a year. The incidence and severity of hypomagnesaemia and its correlation with other biochemical variables were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 138 patients underwent parathyroidectomy for PHPT. Pre\u2010operative and day 1 post\u2010operative serum magnesium levels were available in 57\/138 (41.3%) and 99\/138 (71.7%) patients, respectively. Serum magnesium decreased significantly after surgery (mean\u2009\u00b1\u2009SD of 0.85\u2009\u00b1\u20090.08 and 0.75\u2009\u00b1\u20090.11\u00a0mmol\/L, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). On the day after parathyroidectomy, 31\/99 (31.3%) patients had hypomagnesaemia (&lt;0.70\u00a0mmol\/L); in 3 of whom it was severe (&lt;0.50\u00a0mmol\/L). Patients with hypomagnesaemia had lower pre\u2010operative magnesium (mean\u2009\u00b1\u2009SD of 0.78\u2009\u00b1\u20090.06 and 0.87\u2009\u00b1\u20090.07\u00a0mmol\/L, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), higher pre\u2010operative calcium [median (IQR) of 2.83 (2.71\u20132.99) and 2.71 (2.63\u20132.80) mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.001] and higher post\u2010operative calcium [median (IQR) of 2.41 (2.30\u20132.51) and 2.35 (2.28\u20132.43) mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.046] compared to those with normomagnesaemia. In addition, these patients demonstrated higher drop in calcium levels after surgery (0.44\u2009\u00b1\u20090.20 and 0.35\u2009\u00b1\u20090.18\u00a0mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.033). Magnesium levels after surgery correlated positively with pre\u2010operative magnesium (<jats:italic>r<\/jats:italic>\u2009=\u20090.561, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and post\u2010operative PTH (<jats:italic>r<\/jats:italic>\u2009=\u20090.210, <jats:italic>p<\/jats:italic>\u2009=\u20090.037) and negatively with pre\u2010operative adjusted calcium (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.389, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum magnesium decreased significantly following parathyroidectomy for PHPT and nearly a third of patients developed post\u2010operative, mostly mild hypomagnesaemia. Whilst routine serum magnesium measurements could facilitate prompt recognition and treatment of this electrolyte disturbance, further research needs to establish the clinical importance of mild hypomagnesaemia in these clinical settings and, if indicated, to devise optimal treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05425-1","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T17:02:53Z","timestamp":1581613373000},"page":"1898-1904","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum Magnesium Measurements After Parathyroidectomy for Primary Hyperparathyroidism: Should It be Routine?"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-7586","authenticated-orcid":false,"given":"Peter","family":"Novodvorsky","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"},{"name":"Department of Oncology and Metabolism School of Medicine and Biomedical Sciences University of Sheffield Beech Hill Road S10 2RX Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew F.","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Beverly B.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabapathy P.","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism School of Medicine and Biomedical Sciences University of Sheffield Beech Hill Road S10 2RX Sheffield UK"},{"name":"Department of General Surgery Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-29738-7.00028-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/55.5.523"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050910"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007111194"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20101413"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_599_17"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910116"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420070118021"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(88)90100\u20103"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010198506000\u201000015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010198501000\u201000006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201012\u20100528"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5695.529"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0390281"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5876.391"},{"key":"e_1_2_6_17_1","first-page":"536","article-title":"Persistent hypomagnesaemia following parathyroid surgery, hypermagnesuria as a possible cause","volume":"19","author":"Tambyah PA","year":"1990","journal-title":"Ann Acad Med Singapore"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-020-05425-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-020-05425-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-020-05425-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-020-05425-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T15:18:57Z","timestamp":1703344737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-020-05425-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1007\/s00268-020-05425-1"],"URL":"https:\/\/doi.org\/10.1007\/s00268-020-05425-1","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]},"assertion":[{"value":"13 February 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"PN has served on speaker panels for NovoNordisk and on advisory panels for Sanofi and received travel grants from Eli Lilly and Sanofi. AFL, CBBL and SPB declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}