{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:24:26Z","timestamp":1790162666783,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluated the short\u2010 and long\u2010term outcomes of synchronous resection of liver metastases (LM) from small bowel neuroendocrine tumors (SB\u2010NET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of patients undergoing resection for LMs from SB\u2010NETs from January 1997 and December 2018 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 44 patients with synchronous SB\u2010NET and LMs. Perioperative and 90\u2010day mortality values were zero, and the morbidity rate was 27%. The median overall survival (OS) was 128.4\u00a0months (CI 95% 74.0\u2013161.5\u00a0months) with 1\u2010, 3\u2010, 5\u2010, and 10\u2010year survival rates of 100%, 83%, 79%, and 60%, respectively. Not achieving surgical treatment for LM was the unique independent factor for survival (HR 6.50; CI 95% 1.54\u201327.28; <jats:italic>p\u2009<\/jats:italic>=\u20090.01) in patients with unresected LMs having OS and 10\u2010year survival rates (42\u00a0months, 33%) versus patients undergoing liver resection (152\u00a0months, 66%)(<jats:italic>p\u2009<\/jats:italic>=\u20090.0008). The recurrence rate was 81.8% and associated with longer OS and 5\u2010year survival rates when limited to the liver [223\u00a0months (61%) vs 94\u00a0months (87%)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simultaneous resection of SB\u2010NETs with synchronous LMs was safe and associated with considerable long\u2010term survival even in the presence of bilobar disease. However, recurrence after resection was common (81%) but associated with longer survival rates when limited to the liver.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05467-5","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T15:06:57Z","timestamp":1584371217000},"page":"2377-2384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Outcomes of Simultaneous Resection of Small Bowel Neuroendocrine Tumors with Synchronous Liver Metastases"],"prefix":"10.1002","volume":"44","author":[{"given":"Pietro","family":"Addeo","sequence":"first","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, P\u00f4le des Pathologies Digestives, H\u00e9patiques et de la Transplantation, H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg 1, Avenue Moli\u00e8re 67098 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Baptiste","family":"Bertin","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, P\u00f4le des Pathologies Digestives, H\u00e9patiques et de la Transplantation, H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg 1, Avenue Moli\u00e8re 67098 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Imperiale","sequence":"additional","affiliation":[{"name":"Biophysics and Nuclear Medicine University Hospitals of Strasbourg Strasbourg France"},{"name":"Faculty of Medicine, FMTS University of Strasbourg Strasbourg France"},{"name":"Molecular Imaging\u2010DRHIM IPHC UMR 7178, CNRS\/Unistra Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde","family":"Averous","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, FMTS University of Strasbourg Strasbourg France"},{"name":"Pathology University Hospitals of Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Terrone","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, P\u00f4le des Pathologies Digestives, H\u00e9patiques et de la Transplantation, H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg 1, Avenue Moli\u00e8re 67098 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Goichot","sequence":"additional","affiliation":[{"name":"Internal Medicine, H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bachellier","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, P\u00f4le des Pathologies Digestives, H\u00e9patiques et de la Transplantation, H\u00f4pital de Hautepierre\u2010H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg 1, Avenue Moli\u00e8re 67098 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.01.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6468"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010017\u20105839\u2010x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.06.019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.10.031"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.05.040"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.08.009"},{"key":"e_1_2_7_9_1","unstructured":"FisherAT TitanAL FosterDSet al. 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