{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:43:53Z","timestamp":1793241833151,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100002608","name":"American Thyroid Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA177900"],"award-info":[{"award-number":["K07CA177900"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002608","name":"American Thyroid Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA177900"],"award-info":[{"award-number":["K07CA177900"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Papillary thyroid carcinoma is the most common endocrine malignancy and one of the most common cancers worldwide. However, the optimal timing and frequency of surveillance to assess for recurrence remain undetermined. As the incidence of thyroid cancer continues to rise worldwide, identifying risk factors for recurrence and investigating intervals and durations of surveillance are paramount to adapt treatment and follow\u2010up plans to high\u2010risk individuals and to reduce interventions for low\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our dataset included an unselected cohort of papillary thyroid carcinoma (PTC) patients who underwent a total thyroidectomy (or unilateral then completion thyroidectomy) at a single institution from 2000 to 2007. BRAF genotyping was performed on available specimens by a validated PCR\u2010based assay. Pathologic structural recurrence was the primary outcome. We performed univariate and multivariable analyses to identify predictors of cancer recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 599 patients underwent complete resection of the thyroid gland for PTC. The cohort was young (mean age 45.0 years), predominately female (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009462, 76.9%), and median follow\u2010up was 10.3 years (IQR 5.4\u201312.2). Recurrence occurred more commonly in the BRAF\n                      <jats:sup>V600E<\/jats:sup>\n                      group (18.6 vs. 9.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). BRAF independently predicted PTC recurrence (HR 2.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BRAF mutation is an independent predictor of papillary thyroid carcinoma long\u2010term recurrence. Understanding molecular characteristics of individual thyroid cancers may help risk\u2010stratify patients and direct them toward more appropriate initial care and long\u2010term surveillance strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-020-05521-2","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T10:02:43Z","timestamp":1588068163000},"page":"2685-2691","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["BRAF\n                    <sup>V600E<\/sup>\n                    Mutation is Associated with an Increased Risk of Papillary Thyroid Cancer Recurrence"],"prefix":"10.1002","volume":"44","author":[{"given":"Samuel","family":"Enumah","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital 75 Francis St. CA\u2010034 02115 Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbey","family":"Fingeret","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center 68198 Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareh","family":"Parangi","sequence":"additional","affiliation":[{"name":"Harvard Medical School Massachusetts General Hospital 55 Fruit St, Wang Ambulatory Center 460 02114 Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Dias\u2010Santagata","sequence":"additional","affiliation":[{"name":"Harvard Medical School Massachusetts General Hospital 55 Fruit Street, GRJ222 02114 Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Sadow","sequence":"additional","affiliation":[{"name":"Harvard Medical School Massachusetts General Hospital 55 Fruits Street, WRN219 02114 Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie C.","family":"Lubitz","sequence":"additional","affiliation":[{"name":"Harvard Medical School Massachusetts General Hospital 55 Fruit Street, YAW 7B 02114 Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/965212"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.07.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.0978"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007\u20100007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0241"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3190"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.8253"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1857"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.417"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010013\u20100029\u20105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.4501"},{"key":"e_1_2_8_15_1","first-page":"1050","article-title":"Predicting 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