{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:01:53Z","timestamp":1782363713343,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of adjuvant hepatic intra\u2010arterial infusion chemotherapy (HAI) is considered to be a promising option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined treatment effects of adjuvant HAI using cisplatin in 37 hepatocellular carcinoma (HCC) patients with portal vein infiltration (PVI) who underwent hepatectomy in comparison with those in 85 patients who did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PVI in 89 patients. Increased levels of aspartate transaminase, tumor markers, size and microvessel tumor infiltration (MVI) or cirrhosis, poorly differentiation, non\u2010adjuvant HAI was associated with lower overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). Poor differentiation, MVI and HAI were independently risk factors associated with tumor\u2010free and overall survivals by the multivariate analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Adjuvant HAI tended to show longer survivals in comparison with no\u2010HAI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08) and the multivariate analysis revealed significant efficacy of HAI for better prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjuvant HAI showed effectiveness on prolonging tumor\u2010free and patient survival in HCC with PVI and is a promising option in the daily clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-020-05527-w","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T13:05:41Z","timestamp":1587474341000},"page":"2770-2776","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased Survival Benefit of Adjuvant Intra\u2010arterial Infusion Chemotherapy in HCC Patients with Portal Vein Infiltration after Hepatectomy"],"prefix":"10.1002","volume":"44","author":[{"given":"T.","family":"Hamada","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreas Surgery, Department of Surgery, Faculty of Medicine University of Miyazaki Kihara 5200, Kiyotake 889\u20101692 Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yano","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreas Surgery, Department of Surgery, Faculty of Medicine University of Miyazaki Kihara 5200, Kiyotake 889\u20101692 Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreas Surgery, Department of Surgery, Faculty of Medicine University of Miyazaki Kihara 5200, Kiyotake 889\u20101692 Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Imamura","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreas Surgery, Department of Surgery, Faculty of Medicine University of Miyazaki Kihara 5200, Kiyotake 889\u20101692 Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hiyoshi","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreas Surgery, Department of Surgery, Faculty of Medicine University of Miyazaki Kihara 5200, Kiyotake 889\u20101692 Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreas Surgery, Department of Surgery, Faculty of Medicine University of Miyazaki Kihara 5200, Kiyotake 889\u20101692 Miyazaki Japan"},{"name":"Department of Surgery, Faculty of Medicine 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