{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:06:49Z","timestamp":1784128009504,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mid\u2010term data from a single centre showed the safety and durability of aortic valve neocuspidization using autologous pericardium (OZAKI procedure). Since validation data from other centres are missing, aim of this study was to analyze echocardiographic and clinical results of our first patients that were operated with the OZAKI technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five patients (24\u00a0males, median (IQR) age 72.0 (59.0, 76.0) years) with aortic stenosis (AS; <jats:italic>n<\/jats:italic>\u2009=\u200910), aortic insufficiency (AR; <jats:italic>n<\/jats:italic>\u2009=\u200913) or a combination of both (AS\/AR; <jats:italic>n<\/jats:italic>\u2009=\u200912), underwent aortic valve neocuspidization in our institution between September 2015 and May 2017. Echocardiographic follow\u2010up was performed using a standardized examination protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical follow\u2010up was completed in 97% of the patients. Median (IQR) follow\u2010up time was 645 (430, 813) days. Mortality rate was 9% (<jats:italic>n<\/jats:italic>\u2009=\u20091: aspiration pneumonia; <jats:italic>n<\/jats:italic>\u2009=\u20091: unknown; <jats:italic>n<\/jats:italic>\u2009=\u20091: anaphylactic shock), and the reoperation rate was 3% (<jats:italic>n<\/jats:italic>\u2009=\u20091: endocarditis). No pacemaker implantation was necessary after isolated OZAKI procedures. Echocardiographic follow\u2010up was performed in 83% of the patients (<jats:italic>n<\/jats:italic>\u2009=\u200929; median (IQR) time 664 (497, 815) days). Median (IQR) mean and peak gradients were 6 (5,9) mmHg and 12 (8, 17) mmHg. Moderate aortic regurgitation was seen in 2 patients (7%). No severe aortic regurgitation or moderate or severe aortic stenosis occurred within the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The OZAKI procedure is reliable and reoperation due to structural valve deterioration nil within a median 645\u00a0days follow\u2010up period. The low rate of moderate aortic regurgitation will be surveilled very closely. Further studies are required to evaluate the significance of this procedure in aortic valve surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical registration number<\/jats:title><jats:p>ClinicalTrials.gov (ID NCT03677804)<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05588-x","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T22:02:38Z","timestamp":1590530558000},"page":"3175-3181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Echocardiographic and Clinical Follow\u2010up After Aortic Valve Neocuspidization Using Autologous Pericardium"],"prefix":"10.1002","volume":"44","clinical-trial-number":[{"clinical-trial-number":"nct03677804","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-8600","authenticated-orcid":false,"given":"Luca","family":"Koechlin","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery University Hospital Basel Spitalstrasse 21 CH\u20104031 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schurr","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital Basel Spitalstrasse 21 CH\u20104031 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Miazza","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital Basel Spitalstrasse 21 CH\u20104031 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Imhof","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Hospital Basel Basel 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Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich S.","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital Basel Spitalstrasse 21 CH\u20104031 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Reuthebuch","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital Basel Spitalstrasse 21 CH\u20104031 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.253682"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201014\u20101092"},{"key":"e_1_2_9_5_1","first-page":"w14591","article-title":"Aortic valve replacement 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