{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:52:24Z","timestamp":1791841944069,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010109","name":"Medizinische Universit\u00e4t Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral nerve defects (PND) often cause lifelong physical disability, and the available treatment options are often not satisfactory. PND are usually bridged with an autologous nerve transplant or a nerve guidance conduit (NGC), when coaptation as preferred technique is not possible. The aim of this experimental study was to determine the effectiveness of a novel NGC for regeneration in the treatment of PND.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A conduit made of gelatin with an innovative interior structure was tested for the repair of a 6\u2010mm gap versus direct microsurgical suture repair without gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that bridging the defect with this conduit was as effective as direct microsurgical coaptation without a defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This nerve conduit, effective in bridging neural defects, appears as an alternative to autologous nerve grafts, avoiding the problems related to nerve graft harvesting, host\u2013donor differences in diameter, mismatches in number and pattern of fascicles, cross\u2010sectional shape and area, and morbidity of the donor area.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05620-0","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T13:07:37Z","timestamp":1591621657000},"page":"3373-3382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A New Synthetic Conduit for the Treatment of Peripheral Nerve Injuries"],"prefix":"10.1002","volume":"44","author":[{"given":"Selman","family":"Uranues","sequence":"first","affiliation":[{"name":"Section for Surgical Research, Department of Surgery Medical University of Graz Auenbruggerplatz 29 8036 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Bretthauer","sequence":"additional","affiliation":[{"name":"Institute for Automation and Applied Informatics Karlsruhe Institute of Technology 76344 Eggenstein\u2010Leopoldshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Tomasch","sequence":"additional","affiliation":[{"name":"Section for Surgical Research, Department of Surgery Medical University of Graz Auenbruggerplatz 29 8036 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Rafolt","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Nagele\u2010Moser","sequence":"additional","affiliation":[{"name":"Section for Surgical Research, Department of Surgery Medical University of Graz Auenbruggerplatz 29 8036 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Berghold","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Documentation Medical University of Graz 8036 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Kleinert","sequence":"additional","affiliation":[{"name":"Institute of Pathology Medical University of Graz 8036 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Justich","sequence":"additional","affiliation":[{"name":"Clinical Division of Plastic, Aesthetic and Reconstructive Surgery Medical University of Graz 8036 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Waldert","sequence":"additional","affiliation":[{"name":"State Hospital for Neurology and Psychiatrics 8055 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Koch","sequence":"additional","affiliation":[{"name":"Clinical Division of Plastic, Aesthetic and Reconstructive Surgery Medical University of Graz 8036 Graz 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June 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors state that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This experimental study was approved by the Austrian Federal Ministry of Science, Research and Economy (Authorization Nr. BMWF-66.010\/0082-II\/3b\/2010). In addition, the experimental protocol was approved by the Institutional Review Board of the Medical University of Graz. All animal procedures were performed in accordance with Austrian and European law (Directive 2010\/63\/EU) which are covering all requirements listed in the ARRIVE Guidelines (Animal Research: Reporting\u00a0In Vivo\u00a0Experiments).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}