{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:51:46Z","timestamp":1769550706478,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Laparoscopic liver resection (LLR) may improve outcomes for cirrhotic patients with hepatocellular carcinoma (HCC) and portal hypertension (PHT). The aim of this study was to compare the short\u2010term outcomes after LLR for HCC in cirrhotic patients with and without PHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentric study included 96 HCC patients who underwent LLR. Clinically significant portal hypertension (CSPH) was defined by a hepatic venous pressure gradient \u226510\u00a0mmHg. Short\u2010term outcomes and liver\u2010specific complications including post\u2010hepatectomy liver failure (PHLF), ascites and encephalopathy were compared between patients with and without CSPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients (32%) had CSPH. The CSPH group had higher post\u2010operative morbidity (52% vs. 15%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), PHLF (10% vs. 0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and encephalopathy (10% vs. 0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). There was no difference in terms of post\u2010operative ascites between the two groups (CSPH: 16% vs. no CPSH: 8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.28). The length of stay was longer in patients with CSPH than in those without CSPH (6 vs. 4\u00a0days; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The laparoscopic approach is feasible in selected HCC patients with CSPH, at the price of significant increases in liver\u2010specific complications and length of stay.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05687-9","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T15:03:59Z","timestamp":1594652639000},"page":"3915-3922","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Laparoscopic Liver Resection for Hepatocellular Carcinoma in Child\u2013Pugh A Patients With and Without Portal Hypertension: A Multicentre Study"],"prefix":"10.1002","volume":"44","author":[{"given":"Margarida","family":"Casellas\u2010Robert","sequence":"first","affiliation":[{"name":"Unit of Hepato\u2010Biliary and Pancreatic Surgery, Department of General Surgery Hospital Universitari de Girona Dr. Josep Trueta Av de Fran\u00e7a s\/n 17007 Girona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetana","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Lopez\u2010Ben","sequence":"additional","affiliation":[{"name":"Unit of Hepato\u2010Biliary and Pancreatic Surgery, Department of General Surgery Hospital Universitari de Girona Dr. Josep Trueta Av de Fran\u00e7a s\/n 17007 Girona Catalonia 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP Paul Brousse Hospital Villejuif France"},{"name":"Department of Hepatobiliary and Pancreatic Surgery and Transplantation, Faculty of Medicine, Sheba Medical Center Tel Aviv University Tel Aviv 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