{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:50:31Z","timestamp":1789426231338,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Primary hyperparathyroidism (HPT1) is the most frequent endocrinopathy in multiple endocrine neoplasia type 1 (MEN1). Its surgical management is challenging. We aimed to describe and compare the imaging findings of parathyroid ultrasound (US), sestaMIBI scintigraphy (sestaMIBI), and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorocholine (FCH) PET\/CT in a series of MEN1 patients with HPT1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of a cohort of MEN1 patients with HPT1 assessed by parathyroid US, sestaMIBI scintigraphy and SPECT\/CT, and FCH\u2010PET\/CT for potential surgery between 2015 and 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two patients with a confirmed diagnosis of MEN1 who presented with HPT1 and were assessed by the 3 imaging modalities were included. After imaging workups, 11 patients were operated on for the first time, 4 underwent a redo surgery, and 7 did not undergo an operation. The overall patient\u2010based positivity rate of imaging was 91% (20 of 22) for parathyroid US and 96% (21 of 22) for both sestaMIBI and FCH\u2010PET\/CT. The 3 imaging modalities demonstrated negative findings in 1\/22 patient who did not undergo surgery. Overall, 3 pathologic glands were not detected by any imaging technique. SestaMIBI and FCH\u2010PET\/CT both resulted in the same 3 false\u2010positive results in ectopic areas with a significant uptake on two thymic carcinoid tumors and one inflammatory lymph node. FCH\u2010PET\/CT provided more surgically relevant data than sestaMIBI in 4\/11 patients with initial surgery and in 1\/4 patient who underwent redo surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared to sestaMIBI scintigraphy, FCH\u2010PET\/CT provides additional information regarding the number of pathologic parathyroid glands and their localization in MEN1 patients with HPT1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-020-05695-9","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T16:03:36Z","timestamp":1595001816000},"page":"3761-3769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["<sup>18<\/sup>\n                    F\u2010fluorocholine PET\/CT in MEN1\u00a0Patients with Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4882-9366","authenticated-orcid":false,"given":"Mathieu","family":"Gauth\u00e9","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, H\u00f4pital Tenon, Assistance Publique\u2010H\u00f4pitaux de Paris Sorbonne Universit\u00e9 Paris France"},{"name":"AP\u2010HP Health Economics Research Unit INSERM UMR 1153\u2010CRESS METHODS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dierick\u2010Gallet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris Universit\u00e9 de Paris 27, rue du Faubourg Saint Jacques 75014 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Delbot","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, H\u00f4pital Cochin Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9opoldine","family":"Bricaire","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris Universit\u00e9 de Paris 27, rue du Faubourg Saint Jacques 75014 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Bertherat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris Universit\u00e9 de Paris 27, rue du Faubourg Saint Jacques 75014 Paris France"},{"name":"Universit\u00e9 de Paris Paris France"},{"name":"Institut Cochin, Inserm Unit\u00e9 1016, Centre National de La Recherche Scientifique Unit\u00e9 Mixte de Recherche 8104 Universit\u00e9 de Paris 75014 Paris 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