{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T04:05:33Z","timestamp":1772597133723,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatic neuroendocrine neoplasms (PNENs) are rare neoplasms associated with a long life expectancy after resection. In this setting, patients may benefit from laparoscopic organ\u2010sparing resection. Studies of laparoscopic organ\u2010sparing resection for PNENs are limited. The aim of this study was to evaluate the short\u2010 and long\u2010term outcomes of laparoscopic organ\u2010sparing resection for PNENs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was performed for patients with PNENs who underwent laparoscopic organ\u2010sparing pancreatectomy between March 2005 and May 2018. The patients\u2019 demographic data, operative results, pathological reports, hospital courses and morbidity, mortality, and follow\u2010up data (until August 2018) were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five patients were included in the final analysis. There were 9\u00a0male and 26 female patients, with a median age of 46 years (range 25\u201375 years). The mean BMI was 24.6\u2009\u00b1\u20093.3\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Nine patients received laparoscopic enucleation (LE), 20 received laparoscopic spleen\u2010preserving distal pancreatectomy (LSPDP), and 6 received laparoscopic central pancreatectomy. The operative time, intraoperative blood loss, transfusion rate, and postoperative hospital stay were 186.4\u2009\u00b1\u200960.2\u00a0min, 165\u2009\u00b1\u200973.0\u00a0ml, 0\u00a0days, and 9\u00a0days (range 5\u201323\u00a0days), respectively. The morbidity rate, grade\u2009\u2265\u2009III complication rate, and grade\u2009\u2265\u2009B pancreatic fistula rate were 34.2%, 11.4%, and 8.7%, respectively, with no mortality. The rate of follow\u2010up was 94.3%, and the median follow\u2010up time was 55\u00a0months (range 3\u2013158\u00a0months). One patient developed recurrence 36\u00a0months after LE and was managed with surgical resection. The other patients survived without metastases or recurrence during the follow\u2010up. One patient had diabetes after LSPDP, and no patients had symptoms of pancreatic exocrine insufficiency. Nineteen patients who underwent LSPDP (16 with the Kimura technique and 3 with the Warshaw technique) were followed. Normal patency of the splenic artery and vein was observed in 14 and 14 patients within 1\u00a0month of surgery and in 15 and 14 patients 6\u00a0months or more after the operation, respectively. Partial splenic infarction was observed in 3 patients within 1\u00a0month of surgery and in no patients 6\u00a0months or more after the operation. Three patients eventually developed collateral venous vessels around the gastric fundus and reserved spleen, with one case of variceal bleeding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Laparoscopic organ\u2010sparing resection for selected cases of PNENs is safe and feasible and has favourable short\u2010 and long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-020-05707-8","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T10:06:22Z","timestamp":1595412382000},"page":"3795-3800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Short\u2010 and Long\u2010Term Outcomes of Laparoscopic Organ\u2010Sparing Resection for Pancreatic Neuroendocrine Neoplasms"],"prefix":"10.1002","volume":"44","author":[{"given":"Ren\u2010Chao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal &amp; Pancreatic Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College 158 Shangtang Road 310014 Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal &amp; Pancreatic Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College 158 Shangtang Road 310014 Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ping","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal &amp; Pancreatic Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College 158 Shangtang Road 310014 Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Cheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal &amp; Pancreatic Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College 158 Shangtang Road 310014 Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Wei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal &amp; Pancreatic Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College 158 Shangtang Road 310014 Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal &amp; Pancreatic Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College 158 Shangtang Road 310014 Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010061813\u2010012908"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022\u2010013\u20109295\u20102"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.11.005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010009\u20100224\u20101"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010011\u20100801\u2010z"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i17.4908"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101893\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010016\u20105411\u2010y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010019\u201006901\u2010z"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.11.014"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010009\u20100934\u20103"},{"key":"e_1_2_12_15_1","unstructured":"World Health Organization(2006)Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO\/IDF Consultation"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6609"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010011\u20102108\u20100"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010015\u20104538\u20106"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i37.6272"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13966"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2013.0269"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010017\u20105552\u20107"},{"key":"e_1_2_12_23_1","unstructured":"BosmanFT:WHO classification of tumours of the digestive system; 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The Institutional Review Board of each institute approved this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}