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The aim of this systematic review and meta\u2010analysis was to investigate the impact of accidental hypothermia on mortality in trauma patients overall and patients with traumatic brain injury (TBI) specifically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a systematic review and meta\u2010analysis using the Ovid Medline\/PubMed database. Scientific articles reporting accidental hypothermia and its impact on outcomes in trauma patients were included in qualitative synthesis. Studies that compared the effect of hypothermia vs. normothermia at hospital admission on in\u2010hospital mortality were included in two meta\u2010analyses on (1) trauma patients overall and (2) patients with TBI specifically. Meta\u2010analysis was performed using a Mantel\u2013Haenszel random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Literature search revealed 264 articles. Of these, 14 studies published 1987\u20132018 were included in the qualitative synthesis. Seven studies qualified for meta\u2010analysis on trauma patients overall and three studies for meta\u2010analysis on patients with TBI specifically. Accidental hypothermia at admission was associated with significantly higher mortality both in trauma patients overall (OR 5.18 [95% CI 2.61\u201310.28]) and patients with TBI specifically (OR 2.38 [95% CI 1.53\u20133.69]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the current meta\u2010analysis, accidental hypothermia was strongly associated with higher in\u2010hospital mortality both in trauma patients overall and patients with TBI specifically. These findings underscore the importance of measures to avoid accidental hypothermia in the prehospital care of trauma patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05750-5","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T18:04:00Z","timestamp":1598637840000},"page":"4106-4117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["The Impact of Accidental Hypothermia on Mortality in Trauma Patients Overall and Patients with Traumatic Brain Injury Specifically: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"44","author":[{"given":"David","family":"R\u00f6sli","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Schn\u00fcriger","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Candinas","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Haltmeier","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198709000-00010"},{"key":"e_1_2_7_3_1","unstructured":"Accidental hypothermia in adults \u2010 UpToDate (2019) . 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