{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:29:06Z","timestamp":1785382146449,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Futurum - Academy for Health and Care, Region J\u00f6nk\u00f6ping County, Sweden."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited knowledge about the epidemiology of the major histological subtypes of appendiceal malignancy: adenocarcinoma and neuroendocrine neoplasm of the appendix (A\u2010NEN). The aims of this national cohort study were to assess the prevalence, incidence and trends of appendiceal malignancies in Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All individuals who underwent appendicectomy and all diagnosed with appendiceal malignancy from 1970 to 2012 were identified from the National Patient Register and the Swedish Cancer Registry. Demographic data of the background population were obtained from Statistics Sweden. The incidence rate (IR) and the prevalence of appendiceal malignancy per performed appendicectomy were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 3774 patients with appendiceal malignancy. IR of A\u2010NEN was 5.8\/10<jats:sup>6<\/jats:sup> person\u2010years with a peak of 8.4\/10<jats:sup>6<\/jats:sup> at age 20\u201330 years, whereafter it plateaued at a somewhat lower level. IR for adenocarcinoma was 3.7\/10<jats:sup>6<\/jats:sup> person\u2010years, starting at a very low level among the youngest and increasing to 15.4\/10<jats:sup>6<\/jats:sup> at age 80\u201389 years. The IR of adenocarcinoma increased from 2.6\/10<jats:sup>6<\/jats:sup> in 1970\u20131979 to 5.4\/10<jats:sup>6<\/jats:sup> in 2010\u20132012. The IR of A\u2010NEN was stable during the study period. The prevalence per appendicectomy was low for both types of malignancies among the young but increased with age, most dramatically for adenocarcinoma. There was a trend during the study period towards more extensive surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adenocarcinoma is most common and increasing in the elderly, whereas A\u2010NEN affects all ages with a peak in young age. This peak probably reflects removal of occult A\u2010NEN due to the higher appendicectomy frequency in the young.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05758-x","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T16:03:59Z","timestamp":1599149039000},"page":"4086-4092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidence of Appendiceal Malignancies in Sweden Between 1970 and 2012"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-9460","authenticated-orcid":false,"given":"Joel","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Surgery County Hospital Ryhov J\u00f6nk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland E.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Surgery County Hospital Ryhov J\u00f6nk\u00f6ping Sweden"},{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Landerholm","sequence":"additional","affiliation":[{"name":"Department of Surgery County Hospital Ryhov J\u00f6nk\u00f6ping Sweden"},{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Red\u00e9en","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Surgery Link\u00f6ping University Hospital 581 85 Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/2010-0073-CCR.1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/134.6.864"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10589"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010012\u20102238\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010014\u20102726\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21888"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699\u20100463.1991.tb01241.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.04.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.341"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101318.2010.02457.x"},{"key":"e_1_2_8_13_1","unstructured":"Statistics CBo(2017)Statistikdatabasen.https:\/\/www.statistikdatabasen.scb.se\/pxweb\/sv\/ssd\/START__BE__BE0101__BE0101A\/BefolkningR1860\/?rxid=6fe9e41d\u2010f130\u201044da\u2010928b\u201043eb297669b3. Accessed 21 Aug 2018"},{"key":"e_1_2_8_14_1","unstructured":"Surveillance E End Results program.Standard populations\u201419 age groups.https:\/\/seer.cancer.gov\/stdpopulations\/stdpop.19ages.html. Accessed 21 Aug 2018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010013\u20101714\u20109"},{"key":"e_1_2_8_16_1","first-page":"236","article-title":"Wachsende appendicitismortalit\u00e4t","volume":"72","author":"Nystr\u00f6m G","year":"1932","journal-title":"Acta Chir Scand"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6921.107"},{"key":"e_1_2_8_18_1","unstructured":"The Swedish National Board of Health and Welfare.National Patient Register. Cited 07 July 2020"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443165"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101642051"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.06.015"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-020-05758-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00268-020-05758-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-020-05758-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-020-05758-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T17:34:24Z","timestamp":1703352864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-020-05758-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1007\/s00268-020-05758-x"],"URL":"https:\/\/doi.org\/10.1007\/s00268-020-05758-x","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"assertion":[{"value":"16 August 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Regional Ethical Review Board at Link\u00f6ping University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}}]}}