{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:39:06Z","timestamp":1787647146993,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004337","name":"St. George's University of London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004337","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The United Kingdom Registry of Endocrine and Thyroid Surgeons is a national database holding details on\u2009&gt;\u200928,000 parathyroidectomies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An extract (2004\u20132017) of the database was analysed to investigate the reported efficacy, safety and use of intra\u2010operative surgical adjuncts in targeted parathyroidectomy (tPTx) and bilateral neck exploration (BNE) for adult, first\u2010time primary hyperparathyroidism (PHPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      50.9% of 21,738 cases underwent tPTx. Excellent short\u2010term (median follow\u2010up 35\u00a0days) post\u2010operative normocalcaemia rates were reported overall (tPTx 96.6%, BNE 94.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and in image\u2010positive cases (tPTx 96.7%, BNE 96%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Intra\u2010operative PTH improved overall normocalcaemia rates (tPTx 97.8% vs 96.3%, BNE 95% vs 94.4%: both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Intra\u2010operative nerve monitoring reduced vocal cord (VC) dysfunction in image\u2010positive tPTx, but not in BNE (97.8% vs 93.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Complications were higher following BNE (7.4% vs 3.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), especially hypocalcaemia (5.3% vs 2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). There was no difference in rates of subjective dysphonia following tPTx or BNE (2.4% vs 2.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05), nor any difference in VC dysfunction when formally examined (4.9% vs 4.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In image\u2010positive, first time, adult PHPT cases, tPTx is as safe and effective as BNE, with both achieving excellent short\u2010term results with minimal complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-020-05885-5","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T10:03:10Z","timestamp":1606903390000},"page":"782-789","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Review of Parathyroid Surgery for Primary Hyperparathyroidism from the United Kingdom Registry of Endocrine and Thyroid Surgery (UKRETS)"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-4899","authenticated-orcid":false,"given":"H.","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of ENT, Head &amp; Neck Surgery St George's Hospital Blackshaw Road, Tooting SW17 0QT London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Stechman","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery University Hospital Wales Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Watkinson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aspinall","sequence":"additional","affiliation":[{"name":"Department of General Surgery Aberdeen Royal Infirmary Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of ENT, Head &amp; Neck Surgery St George's Hospital Blackshaw Road, Tooting SW17 0QT London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Overview | Hyperparathyroidism (primary): diagnosis assessment and initial management | Guidance | NICE. NICE. 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