{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:20:32Z","timestamp":1761974432123},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of post\u2010liver resection recurrence is often the life\u2010limiting factor in HCC treatment. While much has been published on intrahepatic recurrence and lung metastasis, there is a relative lack of data on intraabdominal extrahepatic metastasis (EHM). We sought to evaluate the outcomes of patients post\u2010resection of intraabdominal EHM and assess preoperative factors predictive of early recurrence post\u2010metastasectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of 25 consecutive patients who underwent metastasectomy for intraabdominal EHM from 2003 to 2016 at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 25 cases of EHM, 16 were in the peritoneum, 3\u00a0in the adrenal glands, 3\u00a0in the large bowel, 1\u00a0in the spleen, 1\u00a0in the pancreas and 1\u00a0in the omentum. Median overall survival was 27\u00a0months (IQR 15\u201389\u00a0months). Twenty\u2010one patients (84%) developed recurrence post\u2010metastasectomy of EHM of which 12 patients experienced early recurrence within 12\u00a0months. The median time to recurrence post\u2010metastasectomy was 11(IQR 15.5) months. Multivariate analysis demonstrated both hepatitis B (11 (91.6%) versus 4 (44.4%), <jats:italic>p<\/jats:italic>\u2009=\u20090.00) status and high tumour grade (8 (66.6%) versus 3 (25%), <jats:italic>p<\/jats:italic>\u2009=\u20090.004) to be significant independent predictors of early recurrence. Patients who experienced early recurrence had a significantly shorter median overall survival (18\u00a0months (95% CI 12.9\u201323.0)) compared to those who did not (89\u00a0months (95% CI 24.8\u2013153.1), <jats:italic>p<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with EHM who underwent metastasectomy had a median overall survival of 27\u00a0months. Hepatitis B positivity and high primary tumour grade were preoperative predictors of futile surgery. All 7 patients who had both hepatitis B and high tumour grade experienced early recurrence post\u2010metastasectomy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05907-2","type":"journal-article","created":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T19:02:33Z","timestamp":1612119753000},"page":"1144-1151","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preoperative Predictors of Futile Resection of Intraabdominal Extrahepatic Metastases from Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Yun","family":"Le Linn","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u2010Xin","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"},{"name":"Duke\u2010National University of Singapore (NUS) Medical School 8 College Road 169857 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierce K. H.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"},{"name":"Duke\u2010National University of Singapore (NUS) Medical School 8 College Road 169857 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Yip","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"},{"name":"Duke\u2010National University of Singapore (NUS) Medical School 8 College Road 169857 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y. F.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"},{"name":"Duke\u2010National University of Singapore (NUS) Medical School 8 College Road 169857 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"London L. P. J.","family":"Ooi","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"},{"name":"Duke\u2010National University of Singapore (NUS) Medical School 8 College Road 169857 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian K. P.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Level 5, 20 College Road, Academia 169856 Singapore Singapore"},{"name":"Duke\u2010National University of Singapore (NUS) Medical School 8 College Road 169857 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1456"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950050299"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.9.984"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009956"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010018\u20104006\u20104"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010016\u20105713\u20102"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010014\u20101230\u20106"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810730"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.07.024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780578"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1365\u2010182X(17)30755\u20104"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010018\u20104828\u2010y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.03.219"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2009.05848.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950200210"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20773"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.03.044"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25281"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9489"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30237"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","unstructured":"LinnYL CheeMY KohYX TeoJY CheowPC ChowPKHet al (2020) Actual 10\u2010year survivors and 10\u2010year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: a single institution contemporary experience.J Surg Oncol.https:\/\/doi.org\/10.1002\/jso.26259","DOI":"10.1002\/jso.26259"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-020-05907-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-020-05907-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-020-05907-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-020-05907-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T17:49:27Z","timestamp":1704649767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-020-05907-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,31]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1007\/s00268-020-05907-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-020-05907-2","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,31]]},"assertion":[{"value":"5 December 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There is no conflict of interests from all 8 authors of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}