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High air pressure deactivates bacteria and is utilized for commercial food preservation, assuring microbiologically safe pharmaceuticals and sanitizing instruments. However, research on utilizing air pressure deactivation thresholds in surgical and postoperative rooms to reduce rates of SSIs is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study of 801 CABG patients, 128 SSI cases and 673 controls was conducted from January 1, 2006 through March 31, 2009\u00a0in Yerevan, Armenia. Patient and surgery characteristics, air pressure measurements and seasons were selected as independent variables with SSI rates as the outcome. The novel threshold regression analysis was used to determine potential air pressure bacterial deactivation thresholds. A final multivariate logistic regression model adjusted for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, bacterial deactivation air pressure threshold was 694.2\u00a0mmHg, with the presence of infection for higher air pressure values not statistically significant from zero. Individual deactivation thresholds for <jats:italic>Staphylococcus epidermidis<\/jats:italic> (threshold\u2009=\u2009694.2\u00a0mmHg) and <jats:italic>Escherichia coli<\/jats:italic> (threshold\u2009=\u2009689.2) showed similar patterns. Multivariate logistic regression showed air pressure above the deactivation threshold was highly protective against SSIs with adjOR\u2009=\u20090.27 (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.009, 95%CI: 0.10\u20130.72). Other SSI risk factors included female sex, adjOR\u2009=\u20092.12 (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.006, 95%CI: 1.24\u20133.62), diabetes, adjOR\u2009=\u20092.61 (<jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u20090.001, 95%CI: 1.72\u20133.96) and longer time on ventilator, adjOdds\u2009=\u20091.01 (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.012, 95%CI: 1.00\u20131.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maintaining air pressures in operating and postoperative rooms exceeding bacterial\u2010deactivation thresholds might substantially reduce SSI rates following surgery. Further research should identify specific bacterial\u2010deactivation air pressure thresholds in surgical and postoperative rooms to reduce SSI rates, especially for drug\u2010resistant bacteria.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-020-05932-1","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T20:14:20Z","timestamp":1610741660000},"page":"1088-1095","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Higher Surgery and Recovery Room Air Pressures Associated with Reduced Surgical Site Infection Risk"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-1874","authenticated-orcid":false,"given":"Byron L.","family":"Crape","sequence":"first","affiliation":[{"name":"School of Medicine Nazarbayev University 5\/1 Kerei, Zhanibek Khans Avenue, office #453 010000 Nursultan Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-8645","authenticated-orcid":false,"given":"Arnur","family":"Gusmanov","sequence":"additional","affiliation":[{"name":"School of Medicine Nazarbayev University 5\/1 Kerei, Zhanibek Khans Avenue 010000 Nursultan Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-3714","authenticated-orcid":false,"given":"Binur","family":"Orazumbekova","sequence":"additional","affiliation":[{"name":"School of Medicine Nazarbayev University 5\/1 Kerei, Zhanibek Khans Avenue 010000 Nursultan Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-2590","authenticated-orcid":false,"given":"Karapet","family":"Davtyan","sequence":"additional","affiliation":[{"name":"Tuberculosis Research and Prevention Center NGO 6\/2 Adonts Str, Suite 115 0014 Yerevan Armenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy274"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.05.026"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2019.01.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102334\u201014\u2010318"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"Bustamante\u2010MunguiraJ Herrera\u2010G\u00f3mezF Ruiz\u2010\u00c1lvarezMet al. 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