{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:37:30Z","timestamp":1768912650807,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute cholecystitis is one of the most common acute surgical diseases. Diabetic patients have been shown to have an increased risk for gallbladder disease, but the correlation between the severity of gallstone disease and diabetes is still debated. The aim of this study is to examine the possible difference in the disease process between patients with diabetes mellitus (DM) and those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A retrospective study was conducted of all patients who underwent percutaneous cholecystostomy between 2005 and 2015 at Emek Medical Center, Afula, Israel. Demographic and medical history including data on bile and blood culture results, antimicrobial susceptibility, and clinical outcomes were retrieved from patient files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 272 patients. Mean age was 68 years old, 50.74% were male and 43.75% had diabetes mellitus. Bile cultures were obtained from 252 (92.64%) patients and were positive in 134 (53.2%) patients. In 11 patients (4%) two pathogens were isolated. Blood cultures obtained from 231 patients and were positive in 35 (15.2%). <jats:italic>Escherichia coli<\/jats:italic> was the most common isolate, and was seen in 22.3% of positive bile cultures and 40% of blood cultures. Although diabetic patients had significantly more positive bile cultures, the severity of the disease, according to the Tokyo guidelines, was not higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute cholecystitis was neither more severe nor had significant difference in bacteriological properties when comparing diabetic patients to non\u2010diabetic ones.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06107-2","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T16:04:44Z","timestamp":1618502684000},"page":"2426-2431","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Bacteriology of Acute Cholecystitis: Comparison of Bile Cultures and Clinical Outcomes in Diabetic and Non\u2010Diabetic Patients"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1584-1879","authenticated-orcid":false,"given":"Uri","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of General Surgery B Emek Medical Center Yitzhak Rabin Boulevard 21 1834111 Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chovav","family":"Handler","sequence":"additional","affiliation":[{"name":"Department of General Surgery B Emek Medical Center Yitzhak Rabin Boulevard 21 1834111 Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana","family":"Chazan","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Emek Medical Center Yitzhak Rabin Boulevard 21 1834111 Afula Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology, Efron st. 1, Bat Galim, 3525433 Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of General Surgery B Emek Medical Center Yitzhak Rabin Boulevard 21 1834111 Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ossama A.","family":"Hatoum","sequence":"additional","affiliation":[{"name":"Department of General Surgery B Emek Medical Center Yitzhak Rabin Boulevard 21 1834111 Afula Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology, Efron st. 1, Bat Galim, 3525433 Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Yanovskay","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Emek Medical Center Yitzhak Rabin Boulevard 21 1834111 Afula Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology, Efron st. 1, Bat Galim, 3525433 Haifa 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