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The aim of the present study was to evaluate the association of indocyanine green retention test with portal pressure by the cause of cirrhosis (non\u2010viral vs. viral) and assessed postoperative outcomes including incidence of PHLF in patients with viral and non\u2010viral cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort includes 50 consecutive patients with liver cirrhosis scheduled for liver resection for primary liver tumors at the Lausanne University Hospital between 2009 and 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 31 patients with non\u2010viral liver cirrhosis (Non\u2010virus group) and 19 with viral liver cirrhosis (virus group). The indocyanine green retention rate at 15\u00a0min (ICG\u2010R15) (<jats:italic>p<\/jats:italic>\u2009=\u20090.276), Hepatic Venous Portal Gradient (HVPG; <jats:italic>p<\/jats:italic>\u2009=\u20090.301), and postoperative outcomes did not differ between the non\u2010virus group and viral group. ICG\u2010R15 and HVPG showed a significant linear correlation in all patients (Spearman's rank correlation coefficient, <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.599, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), the non\u2010virus group (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.555, <jats:italic>p<\/jats:italic>\u2009=\u20090.026), and the virus group (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.534, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). A receiver operating characteristic curve analysis showed that ICG\u2010R15 was a predictor for presence of portal hypertension (PH; HVPG\u2009\u2265\u200912\u00a0mmHg) (area under the curve [AUC]\u2009=\u20090.780). The cut\u2010off value of ICG\u2010R15 for predicting the presence of PH was 16.0% with 72.3% of sensitivity and 79.0% of specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ICG\u2010R15 level was associated with portal pressure in both patients with non\u2010virus cirrhosis and patients with virus cirrhosis and predicts the incidence of PH with relatively good discriminatory ability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial number<\/jats:title><jats:p>https:\/\/clinicalTrials.gov(ID:NCT00827723)<\/jats:p><\/jats:sec><jats:sec><jats:title>Local ethics committee number<\/jats:title><jats:p>CER\u2010VD 251.08<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06111-6","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T23:19:28Z","timestamp":1619306368000},"page":"2546-2555","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlation Between Portal Pressure and Indocyanine Green Retention Rate is Unaffected by the Cause of Cirrhosis: A Prospective Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-351X","authenticated-orcid":false,"given":"Kosuke","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery Lausanne University Hospital and University of Lausanne Rue du Bugnon 46 1011 Lausanne Switzerland"},{"name":"Hepato\u2010Pancreatico\u2010Biliary Surgery Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo 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