{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T00:04:45Z","timestamp":1703376285252},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Whether sex has any impact on the risk of lymph node (LN) metastasis (LNM) in patients with early\u2010stage non\u2010small cell lung cancer (NSCLC) remains controversial. Therefore, we aimed to objectively compared the risk of LNM between female and male patients with early\u2010stage NSCLC so as to figure out whether sex\u2010different extent of surgery may be justified for treating these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected clinical data of patients undergoing lobectomy or segmentectomy with systematic hilar and mediastinal LN dissection for clinical stage IA peripheral NSCLC from June 2014 to April 2019. Both multivariate logistic regression analysis and propensity score\u2010matched(PSM) analysis were applied to compare the risk of LNM between female and male patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We finally included a total of 660 patients for analysis. In the analysis of unmatched cohorts, there was no significant different rate of LNM (12.4% Vs 13.9%, <jats:italic>P<\/jats:italic>=0.556), hilar\/intrapulmonary LNM (8.4% Vs 10.7%, <jats:italic>P<\/jats:italic>=0.318) and mediastinal LNM(7.9% Vs 7.5%, <jats:italic>P<\/jats:italic>=0.851) between female and male patients. In the multivariate analysis, sex was not found to be an independent predictor of LN in these patients. Moreover, in the analysis of well\u2010matched cohorts generated by PSM analysis, there was still no significant different rate of LNM (13.8% Vs 13.4%, <jats:italic>P<\/jats:italic>=0.892), hilar\/intrapulmonary LNM (9.1% Vs 11.2%, <jats:italic>P<\/jats:italic>=0.442) and mediastinal LNM (9.1% Vs 6.5%, <jats:italic>P<\/jats:italic>=0.289) between female and male patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sex was not an independent predictor of LNM in early\u2010stage NSCLC and there is no sufficient evidence justifying for sex\u2010different extent of surgical resection for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06136-x","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T17:02:42Z","timestamp":1619370162000},"page":"2610-2618","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Differences in Lymph Node Metastasis Based Upon Sex in Early Non\u2010Small Cell Lung Cancer"],"prefix":"10.1002","volume":"45","author":[{"given":"Han\u2010Yu","family":"Deng","sequence":"first","affiliation":[{"name":"Lung Cancer Center West China Hospital, Sichuan University No.37 Guoxue Alley 610041 Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine West China Hospital, Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Ming","family":"Qiu","sequence":"additional","affiliation":[{"name":"Lung Cancer Center West China Hospital, Sichuan University No.37 Guoxue Alley 610041 Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Xing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Lung Cancer Center West China Hospital, Sichuan University No.37 Guoxue Alley 610041 Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Lung Cancer Center West China Hospital, Sichuan University No.37 Guoxue Alley 610041 Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Lung Cancer Center West China Hospital, Sichuan University No.37 Guoxue Alley 610041 Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2012.06.003"},{"key":"e_1_2_11_4_1","first-page":"203","article-title":"Radiotherapy, lobectomy or sublobar resection? 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