{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:29:13Z","timestamp":1760898553534,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parathyroidectomy (PTx) reportedly increases bone mineral density (BMD) in patients with severe secondary hyperparathyroidism (SHPT). To date, however, there has not been sufficient evidence on predictors of BMD improvement post\u2010PTx for SHPT, an issue the present retrospective cohort study aimed to address.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 173 SHPT patients who underwent total PTx with forearm autograft between 2009 and 2017 were included in the present study. Demographic information, perioperative laboratory data and pre\u2010 and post\u2010PTx BMD values (measured by dual\u2010energy X\u2010ray absorptiometry) were collected from their medical records. The change in BMD post\u2010PTx in the lumbar spine was evaluated as the primary outcome. Then, a multivariate logistic regression analysis was performed for a\u2009\u2265\u200910% increase in BMD post\u2010PTx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the median BMD in the lumbar spine was increased by 8.7% post\u2010PTx. The multivariate logistic regression analysis revealed that age\u2009\u2265\u200970 years (<jats:italic>P<\/jats:italic>\u2009=\u20090.005; odds ratio [OR], 0.138; 95% confidence interval [CI]: 0.034\u20130.555), serum Ca level (<jats:italic>P<\/jats:italic>\u2009=\u20090.017; OR, 0.598; 95% CI: 0.392\u20130.911) and pre\u2010PTx BMD in the lumbar spine (<jats:italic>P<\/jats:italic>\u2009=\u20090.003; OR, 0.013; 95% CI: 0.001\u20130.229) were negatively associated with a\u2009\u2265\u200910% increase in BMD post\u2010PTx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that presurgical age, serum Ca levels and BMD values could better predict an improvement in BMD post\u2010PTx in SHPT patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06186-1","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T14:02:47Z","timestamp":1623852167000},"page":"2777-2784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of Bone Mineral Density Improvement after Parathyroidectomy for Secondary Hyperparathyroidism: A Retrospective Single\u2010Center Analysis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-7841","authenticated-orcid":false,"given":"Manabu","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Tomosugi","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Hiramitsu","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ichimori","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Nagoya Daini Red Cross Hospital Nagoya 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May 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The electronic supplementary material has been updated.","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study protocol was approved by the Institutional Review Board of Nagoya Daini Red Cross Hospital, and the study was conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human rights"}},{"value":"Informed consent for participation could not be obtained from all individual participants, owing to the retrospective nature of the present study. 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