{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:01:15Z","timestamp":1789614075855,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Nature Science Foundation of Fujian province","award":["2019J01447"],"award-info":[{"award-number":["2019J01447"]}]},{"name":"Nature Science Foundation of Fujian province","award":["2020J01974"],"award-info":[{"award-number":["2020J01974"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the efficacy and safety of endoscopic appendix intubation and irrigation (EAI) on acute uncomplicated appendicitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective non\u2010randomized study examined 169 patients with suspected acute uncomplicated appendicitis at The First Affiliated Hospital of Fujian Medical University from October 2015 to 2017. Patients were divided into three groups: endoscopic appendix intubation and irrigation (EAI, <jats:italic>n<\/jats:italic>\u2009=\u200918), laparoscopic appendectomy (LA, <jats:italic>n<\/jats:italic>\u2009=\u200987), and antibiotic alone (A, <jats:italic>n<\/jats:italic>\u2009=\u200964). The treatment success rate, duration of hospitalization, medical costs, operation time, duration of abdominal pain, fasting time, complications, and recurrence were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three groups had no significant differences in baseline characteristics (age, gender, Alvarado score, white blood cell count, and neutrophil count; all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Compared to the LA group, the EAI group had shorter durations of the operation, fasting, and abdominal pain; less use of oral and intravenous antibiotics; and lower medical costs (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Compared to the A group, the EAI group had shorter durations of abdominal pain and hospitalization, and less use of intravenous antibiotics (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The EAI group had no complications, but 3 patients (3.4%) in the LA group had surgery\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EAI is a safe and effective treatment for acute uncomplicated appendicitis. Patients who received EAI had shorter durations of abdominal pain and hospitalization than those who received LA or conservative antibiotic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number and agency<\/jats:title><jats:p>ChiCTR\u2010IPN\u201015006565, Chinese Clinical Trial Registry<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06258-2","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T15:04:54Z","timestamp":1627571094000},"page":"3313-3319","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Endoscopic Appendix Intubation and Irrigation on Acute Uncomplicated Appendicitis"],"prefix":"10.1002","volume":"45","author":[{"given":"Pei\u2010Hong","family":"Zhang","sequence":"first","affiliation":[{"name":"The Endoscope Center The First Afilliated Hospital of Fujian Medical University No.20, Chazhong road, Taijiang District 350005 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-2900","authenticated-orcid":false,"given":"Ze\u2010Hao","family":"Zhuang","sequence":"additional","affiliation":[{"name":"The Endoscope Center The First Afilliated Hospital of Fujian Medical University No.20, Chazhong road, Taijiang District 350005 Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9329"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010009\u20100632\u2010y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010016\u20105245\u20107"},{"key":"e_1_2_7_5_1","first-page":"321","article-title":"Perforating inflammation of the vermiform appendix with special reference to its early diagnosis and treatment","volume":"92","author":"Fitz 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July 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Pei-Hong Zhang, Jing-Jing Wei, Ting-Ting Lian, Ying Jiang, and Ze-Hao Zhuang have no conflict of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the medical ethics committee, People\u2019s Hospital of Changji Hui Autonomous Prefecture, Xinjian (2014-2-002).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study was approved by the hospital\u2019s Internal Review Board, and all patients signed informed consent agreements.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}