{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:11:28Z","timestamp":1768972288476,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gallstones are known to occur quite frequently after gastrectomy. Most of the studies about postoperative cholelithiasis have focused on open gastrectomy, whereas laparoscopic gastrectomy has recently gained popularity as a type of minimally invasive surgery (MIS). Hence, the efficacy of MIS in preventing post\u2010gastrectomy gallstone formation remains to be elucidated. This study aimed to evaluate the risk of gallstone formation after MIS for clinical stage I\/IIA gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1166 patients undergoing gastrectomy for clinical stage I\/IIA gastric cancer between 2009 and 2016 were included in this study. Gallstones were detected on abdominal ultrasound and\/or computed tomography. Multivariate logistic regression analysis was used to determine factors associated with postoperative gallstone formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gallstone formation was observed in 174 patients (15%), of whom 22 (2%) experienced symptomatic cholelithiasis. In multivariate analysis, the following were identified as risk factors for post\u2010gastrectomy gallstone formation: open approach with an odds ratio (OR) of 1.670 and a 95% confidence interval (CI) of 1.110\u20132.510 (<jats:italic>P<\/jats:italic>\u2009=\u20090.014), older age (OR 1.880; 95% CI 1.290\u20132.730; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), high body mass index (OR 1.660; 95% CI 1.140\u20132.420; <jats:italic>P<\/jats:italic>\u2009=\u20090.008), Roux\u2010en\u2010Y (RY) reconstruction (OR 1.770; 95% CI 1.230\u20132.530; <jats:italic>P<\/jats:italic>\u2009=\u20090.002), hepatic branch vagotomy (OR 1.600; 95% CI 1.050\u20132.440; <jats:italic>P<\/jats:italic>\u2009=\u20090.029), and intra\u2010abdominal infectious complications (OR 3.040; 95% CI 1.680\u20135.490; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggested that MIS along with the preservation of the hepatic vagus nerve and non\u2010RY reconstruction could help prevent post\u2010gastrectomy gallstone development.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06270-6","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T18:02:41Z","timestamp":1628877761000},"page":"3378-3385","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Minimally Invasive Gastrectomy for Gastric Cancer on Postoperative Gallstone Formation"],"prefix":"10.1002","volume":"45","author":[{"given":"Ko","family":"Ikegame","sequence":"first","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center 1007 Shimonagakubo, Nagaizumi\u2010cho, Sunto\u2010gun 411\u20108777 Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hikage","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center 1007 Shimonagakubo, Nagaizumi\u2010cho, Sunto\u2010gun 411\u20108777 Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fujiya","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center 1007 Shimonagakubo, Nagaizumi\u2010cho, Sunto\u2010gun 411\u20108777 Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center 1007 Shimonagakubo, Nagaizumi\u2010cho, Sunto\u2010gun 411\u20108777 Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Tanizawa","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center 1007 Shimonagakubo, Nagaizumi\u2010cho, Sunto\u2010gun 411\u20108777 Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuro","family":"Bando","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center 1007 Shimonagakubo, Nagaizumi\u2010cho, Sunto\u2010gun 411\u20108777 Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Notsu","sequence":"additional","affiliation":[{"name":"Clinical Research Center Shizuoka Cancer Center Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Terashima","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center 1007 Shimonagakubo, Nagaizumi\u2010cho, Sunto\u2010gun 411\u20108777 Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00311307"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.2.877"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_91_17"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015932"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2019.19.e37"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010006\u20109107\u20103"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010009\u20100832\u20108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.07.035"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445\u20102197.2007.04396.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368703"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"WangCJ KongSH ParkJH et al. 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Ltd., Chugai Pharmaceutical Co. Ltd., Eli Lilly Japan, Ono Pharmaceutical Co. Ltd., Bristol Myers Squibb Japan, and Yakult Honsha Co. Ltd. Etsuro Bando has received personal fees from the Eizo Corporation, Kanehara-Shuppan, Terumo Corporation, and Eisai. All other authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was waived by the ethical committee owing to the retrospective nature of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This study was approved by the institutional review board of the Shizuoka Cancer Center (Approval No. J2020-95-2020-1-2).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}