{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T18:25:53Z","timestamp":1743445553535,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The neural plexus and lymph nodes around the superior mesenteric artery (LN#14), are the most frequent sites involved by pancreatic head cancer. However the influence of metastases to LN#14 on patients\u2019 prognosis has rarely been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients who underwent pancreatectomy for pancreatic head cancer between January 2010 and December 2018 were selected. The patients with nodal metastases were classified into an LN#14\u2009+\u2009or LN#14\u2212group according to LN#14\u00a0metastasis. Clinical and pathological characteristics and prognosis were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 99 patients underwent pancreatectomy. Ninety\u2010four patients were positive for lymph node metastases and 14 and 80 were classified as LN#14\u2009+\u2009and LN#14\u2009\u2212\u2009, respectively. Postoperative median overall survival (OS) of the LN#14\u2009+\u2009and LN#14\u2009\u2212\u2009groups was 10.2 and 31.1\u00a0months, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Median OS of the LN#14\u2009+\u2009group was worse than that of patients with\u2009\u2265\u20094\u00a0metastatic nodes in the LN#14\u2009\u2212\u2009group (<jats:italic>n<\/jats:italic>\u2009=\u200935, 24.7\u00a0months, <jats:italic>P<\/jats:italic>\u2009=\u20090.002). In multivariate analysis, LN#14\u2009+\u2009(hazard ratio [HR]\u2009=\u20093.89, 95% confidence interval [CI], 1.64\u20138.86) was one of the independent predictors of worse OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It might be feasible to recognize LN#14\u00a0metastases as an important prognostic factor independently from other regional lymph node metastases.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06276-0","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T14:03:20Z","timestamp":1629295400000},"page":"3668-3676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Lymph Node Metastases Around the Superior Mesenteric Artery on Postoperative Outcomes of Pancreatic Head Cancer"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-4477","authenticated-orcid":false,"given":"Yoichi","family":"Miyata","sequence":"first","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Yonamine","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibuki","family":"Fujinuma","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takazumi","family":"Tsunenari","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Takihata","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Einama","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Ibaraki Prefectural Central Hospital 309\u20101793 Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Kishi","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Hospital 3\u20102 Namiki 359\u20108513 Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000814"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010007\u20109587\u20101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010015\u20100510\u20100"},{"volume-title":"TNM Classification of Malignant Tumors","year":"2017","author":"Brierley J 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