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This meta\u2010analysis aimed to compare the outcomes of hybrid laparoscopic pancreatoduodenectomy versus open pancreatoduodenectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature research was performed according to PRISMA guidelines. A broad search strategy with terms \u201claparoscopy\u201d and \u201cpancreatoduodenectomy\u201d was used. Included studies were analyzed by quantitative meta\u2010analysis using the metafor package for R software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 655 identified articles, 627 were excluded and 28 articles fully assessed, including 14 comparative studies, 8 case series and 6 case reports. Extracted data included intraoperative variables and postoperative outcome parameters. The predefined inclusion criteria were met by 14 comparative studies, and 371 patients were pooled in the meta\u2010analysis. Hybrid laparoscopic pacreatoduodenectomy was associated with significantly longer operative time (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 0%, <jats:italic>p<\/jats:italic>\u2009=\u20090,01, Mean HPD 494,6\u00a0min, Mean OPD 421,6\u00a0min, WMD 67\u00a0min, 95% CI 14\u2013120\u00a0min). For all other postoperative outcome parameters, no statistically significant differences were found. A nonsignificant reduction in intraoperative transfusion rate (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 20%, <jats:italic>p<\/jats:italic>\u2009=\u20090,2, proportion HPD 2%, proportion OPD 1,6%, OR 0,44, 95% CI 0,16\u20131,27) and blood loss (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 95%, <jats:italic>p<\/jats:italic>\u2009=\u20090,1, Mean HPD 397,2\u00a0ml, Mean OPD 1017,8\u00a0ml, MD \u2212\u2009601\u00a0ml, 95% CI \u2212\u20091311\u2013108) was observed for hybrid pancreatoduodenectomy in comparison to open surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis demonstrates significantly increased operation time for hybrid laparoscopic compared to open pancreatoduodenectomy. Intraoperative variables as well as postoperative parameters and major morbidity were comparable for both techniques. Overall results of this meta\u2010analysis demonstrated the hybrid technique as a safe procedure in high\u2010volume centers offering aspects of a safe transition to fully laparoscopic pancreatoduodenectomy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06372-1","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T18:04:24Z","timestamp":1642529064000},"page":"901-915","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hybrid Laparoscopic Versus Open Pancreatoduodenectomy. 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