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This study aimed to evaluate the efficacy and safety of bariatric surgery in obese cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, and the Cochrane Library were searched for relevant studies. Effectiveness outcomes were weight loss, remission of comorbidities, and improvement in liver function. Safety outcomes were procedural complications and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 studies were included in this meta\u2010analysis. Patients with compensated cirrhosis lost weight significantly after surgery, and the percentage of excess weight loss was 60.44 (95% CI, 44.34 to 76.55). Bariatric surgery resulted in remission of NAFLD in 57.9% (95% CI, 27.5% to 88.3%), T2DM in 58.4% (95% CI, 48.4% to 68.4%), hypertension in 53.1% (95% CI, 43% to 63.3%), dyslipidemia in 59.8% (95% CI, 41.1% to 78.5%) of patients with cirrhosis. Bariatric surgery reduced the levels of alanine aminotransferase and aspartate aminotransferase. The incidence of surgical complications in patients with cirrhosis was about 19.2% (95% CI, 11.7% to 26.6%), which was higher than that in patients without cirrhosis (OR 2.67 [95% CI, 1.26 to 5.67]). Patients with cirrhosis had an overall mortality rate of 1.3%, and the mortality rates for compensated cirrhosis and decompensated cirrhosis were 0.9% and 18.2%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bariatric surgery is effective for weight loss, remission of comorbidities, and reversal of liver damage. Although cirrhotic patients have a higher risk of complications and death, bariatric surgery is relatively safe for well\u2010compensated cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06382-z","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T14:02:52Z","timestamp":1647007372000},"page":"1122-1133","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Bariatric Surgery is Effective and Safe for Obese Patients with Compensated Cirrhosis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"46","author":[{"given":"Jie","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jia","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Fourth Department of Liver Disease (Difficult &amp; Complicated Liver Diseases and Artificial Liver Center) Beijing Youan Hospital Affiliated to Capital Medical University Beijing China"},{"name":"Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujun","family":"Zheng","sequence":"additional","affiliation":[{"name":"First Department of Liver Disease Beijing Youan Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Duan","sequence":"additional","affiliation":[{"name":"Fourth Department of Liver Disease (Difficult &amp; Complicated Liver Diseases and Artificial Liver Center) Beijing Youan Hospital Affiliated to Capital Medical University Beijing China"},{"name":"Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60814\u20103"},{"key":"e_1_2_10_3_1","unstructured":"ZobairMY AaronBK DinanA YousefF LindaH MarkWGlobal epidemiology of nonalcoholic fatty liver disease\u2010meta\u2010analytic assessment of prevalence incidence and outcomes.Hepatology(2016)10.1002\/hep.28431\u201028484"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2298"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"WirthKM ShekaAC KizyS IreyR BennerA SiegerG SimonG MaS LakeJ AliferisC LeslieD MarmorS IkramuddinS. 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