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The primary endpoint was the level of circulating endotoxins after hepatectomy. Secondary endpoints were systemic inflammation (inflammatory cytokine levels), post\u2010operative liver function and overall post\u2010operative complication rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From May 2013 to December 2018, 64 patients were randomized, and 54 patients were included in the analysis, 27\u00a0in each arm. No significant change in endotoxin levels was observed over time in either group (<jats:italic>P<\/jats:italic>\u2009=\u20090.299). No difference between the groups in terms of post\u2010operative liver function and overall complication rates was observed. The only differences observed were significant increases in the levels of TNFalpha (<jats:italic>P<\/jats:italic>\u2009=\u20090.019) and interleukin 1\u2010b (<jats:italic>P<\/jats:italic>\u2009=\u20090.028) in the probiotic group in the post\u2010operative period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contrary to the modest data reported in the literature, the administration of probiotics before minor liver resection for hepatocellular carcinoma developed in the setting of compensated chronic liver disease does not seem to have an impact on circulating endotoxin levels or post\u2010operative complication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>Trial registration: NCT02021253.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06388-7","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T17:02:41Z","timestamp":1637946161000},"page":"656-665","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Influence of Probiotics Administration Before Liver Resection in Patients with Liver Disease: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"46","clinical-trial-number":[{"clinical-trial-number":"nct02021253","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-6449","authenticated-orcid":false,"given":"Edouard","family":"Roussel","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery Rouen University Hospital 1 rue de Germont 76031 Rouen Cedex France"},{"name":"H\u00f4pital Charles\u2010Nicolle (Rouen) 37 Boulevard Gambetta 76038 Rouen Cedex 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