{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T05:10:53Z","timestamp":1768194653969,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite numerous studies of peripancreatic inflammatory fluid collection (PIFC) that report on the relevance of the drain amylase concentration (D\u2010AMY), early prediction using this assay is problematic. This study aimed to investigate the clinical significance of measuring the D\u2010AMY at 3 h after gastrectomy (POD0) for gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective analysis included consecutive patients who underwent gastrectomy combined with peripancreatic lymph node dissection. The predictive value of D\u2010AMY on POD0 and postoperative day 1 (POD1) for clinically relevant PIFC was evaluated together or individually.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses were performed in 204 patients. Twenty (9.8%) patients experienced PIFC. D\u2010AMY cutoffs of 721 IU\/L on POD0 and 1695 IU\/L on POD1 were determined using the receiver operating characteristic curve analysis for predicting PIFC. The D\u2010AMY on POD0 had higher sensitivity (80%) but lower specificity (66.3%) for prediction of PIFC, compared with those of D\u2010AMY on POD1 (65%, 89.1%, respectively). When combination marker analysis was performed, the highest risk group (D\u2010AMY\u2009\u2265\u2009the cutoff values of POD0 and POD1) were associated with an elevated rate of occurrence (44%) and a high positive likelihood ratio (7.36) compared with those of the single cutoff group. The lowest risk group (D\u2010AMY\u2009&lt;\u2009the cutoff values on POD0 and POD1) was associated with a low rate of occurrence (2.5%) and low negative likelihood ratio (0.24) compared with those of the single cutoff group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined measurements of D\u2010AMYs on POD0 and POD1 enhanced early prediction of PIFC after gastrectomy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06401-z","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:05:58Z","timestamp":1641427558000},"page":"648-655","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drain Amylase Concentrations at 3 h After Gastrectomy Enhance Early Prediction of Postoperative Peripancreatic Inflammatory Fluid Collection"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-798X","authenticated-orcid":false,"given":"Koki","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine 65 Tsurumai\u2010Cho, Showa\u2010Ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine 65 Tsurumai\u2010Cho, Showa\u2010Ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine 65 Tsurumai\u2010Cho, Showa\u2010Ku 466\u20108550 Nagoya 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November 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed were approved by a suitably constituted Ethics Committee of the Nagoya University Hospital (Approval No. 2017-0475) and it conforms to the provisions of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}