{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:08:43Z","timestamp":1740107323001,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sentinel lymph node biopsy is the gold standard for axillary assessment of patients with clinically node negative breast cancer. The current internationally accepted methods comprise of the usage of either a radioactive tracer, vital stains or the combination of both. However, in developing countries radioactive tracer is not widely used due to its high cost and limited availability. In addition, the classic retro\u2010areolar blue dye injection has a high failure rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our study aimed to assess the efficacy of patent blue dye injection in the upper outer quadrant of the breast after validation by concurrent usage of radioactive nanocolloid, in comparison with the classic retro\u2010areolar injection in identifying the sentinel node.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized control study involving 279 patients randomly divided into two groups. In group A lateral injection of 1% patent blue dye (validated by radioactive nanocolloid) was used, while subdermal patent blue dye injection in the retro\u2010areolar space was performed in group B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The new technique showed the promising results with lower failure rate (3.4%) in comparison with the classic retro\u2010areolar patent blue injection (13.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lateral injection technique can be result in comparable results to the combination technique with the added benefit of being widely available and a cheaper option especially in developing countries.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-021-06421-9","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T06:07:52Z","timestamp":1641535672000},"page":"829-835","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Intraparenchymal Injection of 1% Patent Blue Dye in the Upper Outer Quadrant of the Breast to Identify Sentinel Lymph Node in Early Retro\u2010Areolar Breast Cancer in Women: A Tertiary Centre Experience in Egypt"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0964-190X","authenticated-orcid":false,"given":"Mina M. B.","family":"Fouad","sequence":"first","affiliation":[{"name":"General Surgery Department, Kasr Al Aini teaching hospital Cairo University 18 A, North road Nottingham NG1 16AD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirilos","family":"Fouad","sequence":"additional","affiliation":[{"name":"South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy M. 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