{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:28:24Z","timestamp":1789140504247,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To study the efficacy of the oral administration of maltodextrin and fructose before major abdominal surgery (MAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, multicenter, parallel\u2010controlled, double\u2010blind study included patients aged 45\u201370 years who underwent elective gastrectomy, colorectal resection, or duodenopancreatectomy. The intervention group (IG) was given 800\u00a0mL and 400\u00a0mL of a maltodextrin and fructose beverage at 10 h and 2 h before MAS, respectively, and the control group (CG) received water under the same experimental conditions. The primary endpoint was insulin resistance index (IRI), and the secondary endpoints were fasting blood glucose, fasting insulin, insulin secretion index, insulin sensitivity index, intraoperative blood glucose, subjective comfort score, and clinical outcome indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 240 cases were screened, of which 231 cases were randomly divided into two groups: 114\u00a0in the IG and 117\u00a0in the CG. No time\u2010treatment effect was detected for any endpoint. The IRI and fasting insulin were significantly lower in the IG than CG after MAS (<jats:italic>p<\/jats:italic>\u2009=\u20090.02 &amp; <jats:italic>P<\/jats:italic>\u2009=\u20090.03). The scores for anxiety, appetite, and nausea were significantly lower in the IG than CG at 1 h before MAS. Compared with baseline, the scores for appetite and nausea decreased in the IG but increased in the CG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The oral administration of maltodextrin and fructose before MAS can improve preoperative subjective well\u2010being and reduce postoperative insulin resistance without increasing the risk of gastrointestinal discomfort.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06455-7","type":"journal-article","created":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T20:02:18Z","timestamp":1655668938000},"page":"2132-2140","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of the Oral Administration of Maltodextrin Fructose Before Major Abdominal Surgery: A Prospective, Multicenter Clinical Study"],"prefix":"10.1002","volume":"46","author":[{"given":"Huanlong","family":"Qin","sequence":"first","affiliation":[{"name":"Department of General Surgery Shanghai Tenth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafu","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Peking University Cancer Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Miao","sequence":"additional","affiliation":[{"name":"Pancreas Center Jiangsu Province Hospital, The first Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shanghai Tenth People's Hospital Shanghai China"},{"name":"Department of General Surgery Shanghai Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Tenth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Pancreas Center Jiangsu Province Hospital, The first Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Peking University Cancer Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua","family":"Lou","sequence":"additional","affiliation":[{"name":"School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Xia","sequence":"additional","affiliation":[{"name":"Jiangsu Chia Tai Fenghai Pharmaceutical Co. 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Other authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the research ethics committee of each hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}