{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:26:05Z","timestamp":1758709565261,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Peritoneal carcinomatosis from appendiceal goblet cell carcinoma (A\u2010GCC) is a rare and aggressive form of appendiceal tumor. Cytoreductive surgery (CRS) and hyperthermic intra peritoneal chemotherapy (HIPEC) was reported as an interesting alternative regarding survival compared to surgery without HIPEC and\/or systemic chemotherapy. Our aim was to evaluate the impact of CRS and HIPEC for patients presenting A\u2010GCC through an international registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective multicenter international database was retrospectively searched to identify all patients with A\u2010GCC tumor and peritoneal metastases who underwent CRS and HIPEC through the Peritoneal Surface Oncology Group International (PSOGI). The post\u2010operative complications, long\u2010term results, and principal prognostic factors were analyzed.\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 83 patients. After a median follow\u2010up of 47\u00a0months, the median overall survival (OS) was 34.6\u00a0months. The 3\u2010 and 5\u2010year OS was 48.5% and 35.7%, respectively. Patients who underwent complete macroscopic CRS had a significantly better survival than those treated with incomplete CRS. The 5\u2010year OS was 44% and 0% for patients who underwent complete, and incomplete CRS, respectively (HR 9.65, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Lymph node involvement and preoperative chemotherapy were also predictive of a worse prognosis. There were 3 postoperative deaths, and 30% of the patients had major complications.\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRS and HIPEC may increase long\u2010term survival in selected patients with peritoneal metastases of A\u2010GCC origin, especially when complete CRS is achieved. Ideally, randomized control trials or more retrospective data are needed to confirm CRS and HIPEC as the gold standard in this pathology.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06498-w","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T09:03:12Z","timestamp":1647248592000},"page":"1336-1343","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An International Registry of Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-6778","authenticated-orcid":false,"given":"Frederic","family":"Mercier","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, CHU Montreal University of Montreal 1000 St\u2010Denis H2X 0C1 Montreal QC Canada"},{"name":"The Department of Surgical Oncology, CHU Lyon Sud, Hospices civils de Lyon University of Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Passot","sequence":"additional","affiliation":[{"name":"The Department of Surgical Oncology, CHU Lyon Sud, Hospices civils de Lyon University of Lyon Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Emmanuel","family":"Bonnot","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Jean Mermoz Hospital Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Cashin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Akademiska Sjukhuset Uppsala University Hospital Uppasala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Ceelen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Gent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Decullier","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique Unit\u00e9 de Recherche Clinique Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"EMR 37\u201038 Lyon 1 University Lyon France"},{"name":"Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique Unit\u00e9 de Recherche Clinique Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Hospices Civils de Lyon Edouard Herriot Hospital University of Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Levine","sequence":"additional","affiliation":[{"name":"Section of Surgical Oncology, Department of General Surgery Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Glehen","sequence":"additional","affiliation":[{"name":"The Department of Surgical Oncology, CHU Lyon Sud, Hospices civils de Lyon University of Lyon Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PSOGI Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"BIG\u2010RENAPE Working 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O. Glehen declared financial activities outside this work in the form of consulting fees from GAMIDA.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}