{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:11:42Z","timestamp":1788577902461,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients undergoing emergency high\u2010risk abdominal surgery potentially suffer from both systemic dehydration and hypovolaemia. Data on the prevalence and clinical impact of electrolyte disturbances in this patient group, specifically the differences in patients with intestinal obstruction (IO) versus perforated viscus (PV) are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients undergoing emergency high\u2010risk abdominal surgery in a standardized perioperative pathway were included in this retrospective single\u2010center cohort study. Electrolytes and arterial blood gas analysis were measured during the early perioperative period. Prevalence and clinical impact of electrolyte disturbances were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 354 patients were included in the study. Preoperative alkalemia dominated preoperatively, significantly more prevalent in IO (45 vs. 32%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), while acidosis was most pronounced postoperatively in PV (49 vs. 28%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Preoperative hypochloraemia and hypokalemia were more frequent in the IO (34 vs. 20% and 37 vs. 25%, respectively). Hyponatremia was highly prevalent in both IO and PV. Pre\u2010 and postoperative hypochloremia were independently associated with 30\u2010day postoperative morbidity and mortality in patients with IO (OR 2.87 (1.35, 6.23)\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006\n                      <jats:italic>,<\/jats:italic>\n                      OR 6.86 (1.71, 32.2)\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009, respectively). Hypochloremic patients presented with reduced long\u2010term survival as compared with the normo\u2010 and hyperchloremic patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Neither plasma sodium nor potassium showed a significant association with outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These observations suggest that acute high\u2010risk abdominal patients have frequent preoperative alkalosis shifting to postoperative acidosis. Both pre\u2010 and postoperative hypochloremia were independently associated with both impaired short\u2010 and long\u2010term outcome in patients with intestinal obstruction, with potential implications for the choice of resuscitations fluids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-022-06499-9","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T09:02:32Z","timestamp":1646816552000},"page":"1325-1335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Electrolyte and Acid\u2013Base Disturbances in Emergency High\u2010Risk Abdominal Surgery, a Retrospective Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-639X","authenticated-orcid":false,"given":"Mirjana","family":"Cihoric","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Hvidovre University Hospital Kettegaard all\u00e9 30, Hvidovre 2650 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Surgical Pathophysiology Unit, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Laks\u00e1foss","family":"Lauritsen","sequence":"additional","affiliation":[{"name":"Gastrounit, Surgical Section Hvidovre Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"H\u00f8jlund","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Hvidovre University Hospital Kettegaard all\u00e9 30, Hvidovre 2650 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai Bang","family":"Foss","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Hvidovre University Hospital Kettegaard all\u00e9 30, Hvidovre 2650 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12326"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9293"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14514"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13721"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.04.009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010008\u20109017\u20102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5049\/EBP.2010.8.2.72"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318265f576"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12123"},{"key":"e_1_2_11_11_1","unstructured":"StelfoxHT AhmedSB ZygunDet al. 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