{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:06:31Z","timestamp":1791612391027,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"John Hunter Charitable Trust"},{"DOI":"10.13039\/501100000774","name":"The University of Newcastle","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid cancer diagnoses are increasing and treatment can lead to significant morbidity. Long\u2010term health\u2010related quality of life (HRQoL) in thyroid cancer is understudied and lacks reference populations. This study compares long\u2010term HRQoL between patients with thyroid cancer or benign disease, following thyroid surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing thyroidectomy between 2000 and 2017 were identified from a pathology database. 696 participants (278\u00a0malignant, 418 benign) were invited to complete a validated disease\u2010specific HRQoL tool, City of Hope\u2014Thyroid Version. Propensity scores were used to adjust for demographic and clinical differences between cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>206 patients (102\u00a0malignant, 104 benign), 71% female, returned surveys a median of 6.5 (range 1\u201319) years after thyroidectomy. Of the cancer cohort, 95% had differentiated thyroid cancer and 83% remained disease\u2010free. There were no significant differences in overall HRQoL scores between groups. In comparison to the benign cohort, cancer patients showed a significant detriment in the social subdomain score (OR 0.10\u20130.96, <jats:italic>p<\/jats:italic>\u2009=\u20090.017) but not in other subdomains (physical, psychological, spiritual). Female gender, increasing BMI and cancer recurrence were significantly associated with decreased overall HRQoL. Compared to the benign cohort, cancer patients reported more personal and family distress associated with diagnosis and treatment, increased future uncertainty, poorer concentration and greater financial burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although no difference in overall HRQoL was found between patients undergoing thyroidectomy for benign or malignant disease, detriments in social well\u2010being may persist many years after surgery. Thyroid cancer patients and their families may benefit from increased supports around the time of diagnosis and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06643-5","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T16:03:52Z","timestamp":1657209832000},"page":"2423-2432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010Term Health\u2010Related Quality of Life Outcomes Following Thyroid Surgery for Malignant or Benign Disease: Deficits Persist in Cancer Survivors Beyond Five Years"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7641-4304","authenticated-orcid":false,"given":"Nicholas D. A.","family":"Blefari","sequence":"first","affiliation":[{"name":"Surgical Services John Hunter Hospital Locked Bag 1, Hunter Regional Mail Centre 2310 Newcastle NSW Australia"},{"name":"University of Newcastle Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Endocrinology John Hunter Hospital Newcastle NSW Australia"},{"name":"University of Newcastle Newcastle NSW Australia"},{"name":"Hunter Medical Research Institute Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvina","family":"Wiadji","sequence":"additional","affiliation":[{"name":"Surgical Services John Hunter Hospital Locked Bag 1, Hunter Regional Mail Centre 2310 Newcastle NSW Australia"},{"name":"University of Newcastle Newcastle NSW 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