{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:45:21Z","timestamp":1773809121304,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Ukraine, there is no established colorectal cancer screening program. We aimed to project the number of screening colonoscopies needed for implementation of various CRC screening strategies in Ukraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We modified a previously developed Markov microsimulation model to reflect the natural history of adenoma and CRC progression among average\u2010risk 50\u201374\u2010year\u2010olds. We simulated colonoscopies needed for the following screening strategies: no screening, fecal occult blood test yearly, FOBT yearly with flexible sigmoidoscopy every 5 years, FS every 5 years, fecal immunohistochemistry test (FIT) yearly, or colonoscopy every 10 years. Assuming 80% screening adherence, we estimated colonoscopies required at 1 and 5 years depending on the implementation rate. In one\u2010way sensitivity analyses, we varied implementation rate, screening adherence, sensitivity, and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Assuming an 80% screening adherence and complete implementation (100%), besides a no screening strategy, the fewest screening colonoscopies are needed with an FOBT program, requiring on average 6,600 and 26,800 colonoscopies per 100,000 persons at 1 and 5 years post\u2010implementation, respectively. The most screening colonoscopies are required with a colonoscopy program, requiring on average 76,600 and 101,000 colonoscopies per 100,000 persons at 1 and 5 years post\u2010implementation, respectively. In sensitivity analyses, the biggest driver of number of colonoscopies needed was screening adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The number of colonoscopies needed and therefore the potential strain on the healthcare system vary substantially by screening test. These findings can provide valuable information for stakeholders on equipment needs when implementing a national screening program in Ukraine.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06656-0","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T17:03:13Z","timestamp":1657818193000},"page":"2476-2486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Colonoscopy Needs for Implementation of a Colorectal Cancer Screening Program in Ukraine"],"prefix":"10.1002","volume":"46","author":[{"given":"Vanessa M.","family":"Welten","sequence":"first","affiliation":[{"name":"Division of General and Gastrointestinal Surgery, Department of Surgery, Brigham and Women's Hospital Harvard Medical School Boston MA USA"},{"name":"Center for Surgery and Public Health Brigham and Women's Hospital, Harvard Medical School 75 Francis Street 02115 Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerollos Nashat","family":"Wanis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomiia","family":"Semeniv","sequence":"additional","affiliation":[{"name":"The University Hospital Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galyna","family":"Shabat","sequence":"additional","affiliation":[{"name":"Department of Surgery Ivano\u2010Frankivsk National Medical University Ivano\u2010Frankivsk Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten F. A. A.","family":"Dabekaussen","sequence":"additional","affiliation":[{"name":"Division of General and Gastrointestinal Surgery, Department of Surgery, Brigham and Women's Hospital Harvard Medical School Boston MA USA"},{"name":"Department of Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Davids","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Massachusetts Memorial Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriy","family":"Beznosenko","sequence":"additional","affiliation":[{"name":"National Cancer Institute Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulana","family":"Suprun","sequence":"additional","affiliation":[{"name":"NGO ArcUA Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dj\u00f8ra I.","family":"Soeteman","sequence":"additional","affiliation":[{"name":"Center for Health Decision Science Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelya","family":"Melnitchouk","sequence":"additional","affiliation":[{"name":"Division of General and Gastrointestinal Surgery, Department of Surgery, Brigham and Women's Hospital Harvard Medical School Boston MA USA"},{"name":"Center for Surgery and Public Health Brigham and Women's Hospital, Harvard Medical School 75 Francis Street 02115 Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010310912"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20038"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/jgo.18.00145"},{"key":"e_1_2_6_5_1","unstructured":"IHME(2022)Global health data exchange seattle WA USA: Institute for Health Metrics and Evaluation (IHME). [cited 2022 March 22]. Available from:https:\/\/ghdx.healthdata.org\/gbd\u2010results\u2010tool"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12962\u2010018\u20100104\u20100"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010015\u20103600\u20105"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i20.4946"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20109276\u201012\u201038"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hpm.2155"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0748\u20107983(95)92483\u20103"},{"key":"e_1_2_6_12_1","volume-title":"National Health Reform Strategy for Ukraine 2015\u20102020","author":"Ministry of Health of Ukraine","year":"2018"},{"issue":"2","key":"e_1_2_6_13_1","first-page":"1","article-title":"Ukraine: health system review","volume":"17","author":"Lekhan V","year":"2015","journal-title":"Health Syst Transit"},{"key":"e_1_2_6_14_1","unstructured":"HajdaLA YerofeyevIA KryzhanivskySA ZasenkoOE MakuchA StebelskyIThe crisis in Crimea and eastern Ukraine \u2010 Russian invasion and annexation of Crimea: Brittanica; [updated June 29 2021; cited 2021 November 19]. Available from:https:\/\/www.britannica.com\/place\/Ukraine\/The\u2010crisis\u2010in\u2010Crimea\u2010and\u2010eastern\u2010Ukraine."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12992\u2010018\u20100439\u20105"},{"key":"e_1_2_6_16_1","article-title":"Implementing health financing policies to overhaul the healthcare delivery system in Ukraine","volume":"5","author":"Avila C","year":"2021","journal-title":"J Hosp Manag Health Policy"},{"key":"e_1_2_6_17_1","unstructured":"EASO(2021)Ukraine: FFM report \u2010 healthcare reform and economic accessibility. 2021 Februrary. Report No."},{"key":"e_1_2_6_18_1","unstructured":"WHO(2019)Ukraine review of helth financing reforms 2016 \u2010 2019. Report No"},{"key":"e_1_2_6_19_1","volume-title":"Enhancing government effectiveness and transparency: the fight against corruption","author":"Steingr\u00fcber S","year":"2020"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106963\u201014\u2010446"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038\u2010013\u20100457\u20102"},{"key":"e_1_2_6_22_1","unstructured":"The World Bank(2019)GDP per capita (current US$) \u2010 Ukraine Washington DC[cited 2020 September 25]. Available from:https:\/\/data.worldbank.org\/indicator\/NY.GDP.PCAP.CD?locations=UA"},{"key":"e_1_2_6_23_1","volume-title":"CANCER IN UKRAINE 2020 \u2010 2021: Incidence, mortality, prevalence and other relevant statistics Kyiv","author":"NCRU","year":"2022"},{"issue":"9","key":"e_1_2_6_24_1","first-page":"1","article-title":"United States life tables eliminating certain causes of death, 1999\u20132001","volume":"61","author":"Arias E","year":"2013","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054967"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2006.00430.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042990"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010328"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010153\u20106\u2010201009210\u201000004"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.6828"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1998.1498"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.39.1.21"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010145\u201012\u2010200612190\u201000004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000544"},{"key":"e_1_2_6_35_1","volume-title":"A language and environment for statistical computing. 3.6","author":"R Development Core Team. R","year":"2020"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.08.2291"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-022-06656-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00268-022-06656-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-022-06656-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-022-06656-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T16:31:59Z","timestamp":1703349119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-022-06656-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,14]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1007\/s00268-022-06656-0"],"URL":"https:\/\/doi.org\/10.1007\/s00268-022-06656-0","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,14]]},"assertion":[{"value":"21 June 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors have any conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}