{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:36:48Z","timestamp":1793817408453,"version":"4.6.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypoparathyroidism is the most frequent complication after total thyroidectomy and, when permanent, it becomes a severe chronic disease. We assessed the usefulness of indocyanine green (ICG) angiography\u2010guided thyroidectomy to reduce the postoperative hypocalcemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study with two consecutive cohorts of patients who underwent total thyroidectomy: historical control group (CG) and angiography\u2010guided thyroidectomy group (AG). In all patients, ICG\u2010angiography was performed at the end of the surgery to predict immediate parathyroid gland (PG) function. In the AG, ICG\u2010angiography was also done after PG identification to show their vascular supply. We compared the rate of postoperative hypocalcemia (calcium supplementation needed due to hypocalcemia symptoms or calcium levels\u2009&lt;\u20091.8\u00a0mmol\/L on the first postoperative day) and permanent hypocalcemia (need of calcium\u2009\u00b1\u2009vitamin D supplementation 12\u00a0months after thyroidectomy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 120 consecutive patients (84 CG; 36 AG). Thyroid cancer was the most common diagnostic (63.1% CG\u201369.4% AG; <jats:italic>p<\/jats:italic>\u2009=\u20090.646) and central neck dissection was also frequent (54.8% CG\u201364.3% AG; <jats:italic>p<\/jats:italic>\u2009=\u20090.468). The AG developed a lower rate of postoperative (26.2\u20135.6%; <jats:italic>p<\/jats:italic>\u2009=\u20090.011) and permanent hypocalcemia (11.9\u20130%; <jats:italic>p<\/jats:italic>\u2009=\u20090.032). The OR for permanent hypocalcemia was 0.673 (95% CI 0.591\u20130.766). A significant higher rate of well vascularized PG at the end of the surgery (score 2) in the AG (39.2\u201352.9%; <jats:italic>p<\/jats:italic>\u2009=\u20090.018) was also seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICG angiography\u2010guided thyroidectomy is a useful tool to identify PG vascularization, allowing a better PG preservation and a significant decrease in hypocalcemia rates.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06683-x","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T18:03:11Z","timestamp":1660068191000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Usefulness of ICG Angiography\u2010Guided Thyroidectomy for Preserving Parathyroid Function"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-2797","authenticated-orcid":false,"given":"Pablo","family":"Moreno\u2010Llorente","sequence":"first","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Hospital Universitari de Bellvitge Universitat de Barcelona, L'Hospitalet de Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-1143","authenticated-orcid":false,"given":"Arantxa","family":"Garc\u00eda\u2010Barrasa","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Hospital Universitari de Bellvitge Universitat de Barcelona, L'Hospitalet de Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-3613","authenticated-orcid":false,"given":"Mireia","family":"Pascua\u2010Sol\u00e9","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Hospital Universitari de Bellvitge Universitat de Barcelona, L'Hospitalet de Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-1379","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Videla","sequence":"additional","affiliation":[{"name":"Clinical Research Support Unit (HUB), Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) (HUB\u2010IDIBELL) Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat Barcelona Spain"},{"name":"Pharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine University of Barcelona L'Hospitalet de Llobregat, Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-9408","authenticated-orcid":false,"given":"Aurema","family":"Otero","sequence":"additional","affiliation":[{"name":"Clinical Research Support Unit (HUB), Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) (HUB\u2010IDIBELL) Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-5632","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Mu\u00f1oz\u2010de Nova","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010IP) Universidad Aut\u00f3noma de Madrid (UAM) Madrid 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July 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was obtained by the Clinical Research Ethical Committee of Hospital Universitari de Bellvitge (codes PR054\/19 and PR004\/22).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}