{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:43:07Z","timestamp":1793335387703,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the increasing evidence provided by recent high\u2010quality studies, the intravenous iron appears to be a reliable therapy for blood administration in geriatric patients with hip fractures. Here, this systematic review and meta\u2010analysis were aimed to assess the effectiveness and safety of intravenous iron in geriatric patients sustaining hip fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Potential pertinent literatures evaluating the effects of intravenous iron in the geriatric patients undergoing hip fractures were identified from Web of Science, PubMed, Embase, and Scopus. We performed a pairwise meta\u2010analysis using fixed\u2010 and random\u2010effects models, and the pooling of data was carried out by using RevMan 5.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four randomized controlled trials and four observational studies conform to inclusion criteria. The results of meta\u2010analysis showed that intravenous iron reduced transfusion rates compared to the control group, yet the result did not reach statistical significance. The intravenous iron was related to lower transfusion volumes, shorter length of stay, and a reduced risk of nosocomial infections. And there was no significant difference in terms of the mortality and other complications between the treatment group and the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence suggests that intravenous iron reduces the transfusion volume, length of hospital stay, and risk of nosocomial infections. It takes about 7\u00a0days for intravenous iron to elevate hemoglobin by 1\u00a0g\/dl and about 1\u00a0month for 2\u00a0g\/dl. The safety profile of intravenous iron is also reassuring, and additional high\u2010quality studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-022-06690-y","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:03:47Z","timestamp":1660122227000},"page":"2595-2606","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Efficacy and Safety of Intravenous Iron in Geriatric Hip Fracture Surgeries: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"46","author":[{"given":"Mu\u2010Min","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics School of Medicine Zhongda Hospital, Southeast University No. 87 Ding Jia Qiao 210009 Nanjing Jiangsu People's Republic of China"},{"name":"School of Medicine Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Orthopaedic Trauma Institute (OTI), Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine Zhongda Hospital, Southeast University Nanjing Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Yu","family":"Chi","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University Nanjing Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics School of Medicine Zhongda Hospital, Southeast University No. 87 Ding Jia Qiao 210009 Nanjing Jiangsu People's Republic of China"},{"name":"School of Medicine Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Orthopaedic Trauma Institute (OTI), Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine Zhongda Hospital, Southeast University Nanjing Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u2010Wang","family":"Sheng","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University Nanjing Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics School of Medicine Zhongda Hospital, Southeast University No. 87 Ding Jia Qiao 210009 Nanjing Jiangsu People's Republic of China"},{"name":"School of Medicine Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Orthopaedic Trauma Institute (OTI), Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine Zhongda Hospital, Southeast University Nanjing Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Kuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics School of Medicine Zhongda Hospital, Southeast University No. 87 Ding Jia Qiao 210009 Nanjing Jiangsu People's Republic of China"},{"name":"School of Medicine Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Orthopaedic Trauma Institute (OTI), Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine Zhongda Hospital, Southeast University Nanjing Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Feng","family":"Rui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics School of Medicine Zhongda Hospital, Southeast University No. 87 Ding Jia Qiao 210009 Nanjing Jiangsu People's Republic of China"},{"name":"School of Medicine Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Orthopaedic Trauma Institute (OTI), Southeast University Nanjing Jiangsu People's Republic of China"},{"name":"Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine Zhongda Hospital, Southeast University Nanjing Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010006\u20100172\u20104"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S291071"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010022\u20101748\u20101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"ZhangY\u2010W CaoM\u2010M LiY\u2010Jet al. 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