{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:13:57Z","timestamp":1790745237969,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bilateral idiopathic hyperaldosteronism (IHA) is responsible for 60% of primary aldosteronism (PA) cases. Medical management is standard of care for IHA. Unilateral adrenalectomy (UA) with the intent of debulking total aldosterone production as a palliative measure remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010center retrospective review (2010\u20132020) of patients undergoing UA with a diagnosis of PA due to IHA (lateralization index [LI] on adrenal venous sampling [AVS]\u2009&lt;\u20094). Demographic, pre\u2010operative, intra\u2010operative, and post\u2010operative variables were assessed. Hypertensive regimens were converted to the WHO Defined Daily Dose (DDD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients were identified, 14, 58% male and mean age 52\u2009\u00b1\u200910 years. Preoperative hypokalemia was present in 22, 92% of patients. Median number of antihypertensives taken was 3 (interquartile range [IQR], 2\u20134) and median DDD was 4 (IQR, 3\u20135.3). Median lateralization index on AVS was 3.52 (range, 1.19\u20133.88). All operations were performed in minimally invasive fashion. There were no conversions to open procedure, ICU admissions, or post\u2010operative complications. Median follow\u2010up was 10.5\u00a0months (range, 1\u2013145\u00a0months). Hypokalemia resolved in 17, 76% of patients at last follow\u2010up. Post\u2010operative median number of antihypertensives taken was 1 (IQR, 1\u20133) and median DDD was 2 (IQR, 0.5\u20132.75) from 4, <jats:italic>P<\/jats:italic>\u2009=\u20090.003. Three (%) patients required continuation of mineralocorticoid receptor antagonists post\u2010operatively. Blood pressure control improved in 65% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unilateral adrenalectomy in the setting of bilateral hyperaldosteronism can improve blood pressure control and stabilize potassium levels in selected patients. Further prospective studies in larger cohorts will be necessary to further define the role of unilateral adrenalectomy in the setting of PA due to bilateral adrenal disease.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06780-x","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T22:02:12Z","timestamp":1665180132000},"page":"314-318","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Unilateral Adrenalectomy for Primary Aldosteronism Due to Bilateral Adrenal Disease Can Result in Resolution of Hypokalemia and Amelioration of Hypertension"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-6678","authenticated-orcid":false,"given":"Thomas","family":"Szabo Yamashita","sequence":"first","affiliation":[{"name":"Department of Surgery Mayo Clinic 200 1st Street 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omair A.","family":"Shariq","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic 200 1st Street 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trenton R.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic 200 1st Street 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L.","family":"Lyden","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic 200 1st Street 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benzon M.","family":"Dy","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic 200 1st Street 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William F.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic 200 1st Street 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bancos","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic 200 1st Street 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic 200 1st Street 55905 Rochester MN 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August 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No authors report any proprietary or commercial interest in any product mentioned or concept discussed in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This single-center retrospective review was approved by the Mayo Foundation Institutional Review Board and complies with all ethical requirements.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individuals included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}